Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction

Prior treatment

• High alcohol consumption, defined as an average of \>28 alcoholic standard units/week in the 12 months prior to the index hospitalization
• Prior severe heart failure (NYHA III-IV)
• Any medication (investigator's discretion) making study participation impractical or precluding required follow-up

Other illness

• Alcohol use disorder (AUDIT score \>20 at screening)
• History of alcohol or substance abuse
• History of gastric ulcer or gastro-intestinal bleeding
• Serious chronic liver disease or liver test elevation (\> 3 times upper limit normal range)
• Personal history of any colon or liver cancer
• Any active malignancy (less than 5 years or ongoing treatment)
• Estimated glomerular filtration rate 15 ml/min/1.73m² or end-stage renal disease
• History of organ transplant

Other

• Naïve to alcohol consumption
• Light alcohol consumption (\<1 standard units by week)
• Severe LV dysfunction at screening (\<30%)
• Participation in another trial testing intervention on similar CV outcomes (investigator's discretion)
• Any medical, geographic, or social factor making study participation impractical or precluding required follow-up.
• Pregnant, breastfeeding or planning to become pregnant within 12 months.

• Hospitalization for acute ST-elevation MI (STEMI) or non ST-elevation MI (NSTEMI) within 365 days prior to screening
• Men and women aged ≥18 years who are capable and willing to provide consent
• ECG ischemic changes, such as persistent or dynamic ST-segment deviation
• Evidence of positive high-sensitive troponin
• Confirmation of coronary heart disease aetiology by angiography
• Capacity to complete study visits with strict adherence to the protocol assignment
• Self-reported average alcohol consumption of between 1 and 28 standard units per week in the 12 months prior to the index hospitalization.