NCT05927792CompletedPhase 2/3
Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders
Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders: a Multicenter, Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 19 May 2026
Brief summary (registry, in English)
This study is a prospective, multicenter, randomized, single-blind controlled trial to enroll 200 children with autism spectrum disorders (ASD). The investigators hope to further explore the effectiveness of accelerated continuous theta-burst stimulation (a-cTBS) over the left primary motor cortex (M1) to improve core symptoms in ASD children based on a previous open-label clinical trial.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 200 (actual)
- First submitted
- 13 Jun 2023
- Start date
- 4 Jul 2023
- Primary completion date
- 25 Oct 2024
- Lead sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Diseases
- Autism
- NCT number
- NCT05927792
What you commit to
- Study type: Interventional · Phase 2/3
- Participants enrolled: 200
- From 4 Jul 2023 to the primary completion date, 25 Oct 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- With metal implants in the body
- Require surgical treatment due to structural abnormalities indicated by brain MRI
- Participants who received other interventions within 4 weeks prior to enrollment.
Other illness
- History of epilepsy or other neurological disease
- With psychiatric/mental disorder (e.g., very early-onset schizophrenia) other than ASD
- Suffer from serious heart disease and/or severe hearing impairment
- Intracranial hypertension
Other
- Diagnosed with genetic and chromosomal abnormalities
- Participating in other clinical trials
Who the study is looking for
- Children aged 4-10 years old
- Meet the diagnostic criteria for ASD of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
- ASD Diagnosis confirmed by the Autism Diagnostic Observation Schedule (ADOS) or Autism Diagnostic Interview, Revised (ADI-R)
- IQ of 50 or above
- Provide written informed consents
Age in the registry: 4 years to 10 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Qilu Hospital of Shandong University Coordinator of this site? Confirm its status | Qilu | China | Unknown status |
| Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Henan Children's Hospital Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.