NCT05930145Recruiting
Results of the Use of Two Stentrievers Simultaneosly Compared With One as a Primary Treatment in Acute Ischemic Stroke
A Randomized Study Comparing the Effectiveness and Security of the Use of Two Stentrievers Simultaneously Versus One Stentriever as a Primary Treatment in Acute Ischemic Stroke Patients.
Source: ClinicalTrials.gov · Last updated 28 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Several studies have demonstrated that simultaneous treatment with two stentrievers (STs) as rescue treatment is very effective, with high recanalization rates even in this group of patients where other revascularization techniques have failed. There has been no observed increase in hemorrhagic complications. Recently, a prospective study has been published where treatment with two ST has been shown to be effective and safe if used as a first-choice treatment (not as rescue) with a successful recanalization rate (eTICI 2c/3) after the first pass of 69%. These results have been reinforced after the publication of a randomized study that confirms, in vitro, the superiority of using two ST over one.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 24 Jun 2023
- Start date
- 14 Mar 2025
- Primary completion date
- 1 Sept 2026
- Lead sponsor
- Fundación EPIC
- Diseases
- Stroke
- NCT number
- NCT05930145
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 14 Mar 2025 to the primary completion date, 1 Sept 2026
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Initiation of treatment with a different technique than the one described.
Other illness
- Advanced or terminal disease with a life expectancy of less than 6 months.
- Evidence of significant hemorrhage or mass effect with midline shift on baseline CT.
Other
- Those described in the usual protocols for mechanical thrombectomy of each hospital.
- Pre-existing functional clinical status greater than 2 according to the mRS clinical scale
- Patients with tandem lesions of dissection or arteriosclerotic origin located in the extracranial internal carotid artery.
- Inability to use a proximal balloon guide catheter.
- Use of aspiration catheter.
- Intracranial atherosclerotic plaque as the cause of occlusion.
- Patient who is participating in another study that may affect this one.
- ASPECTS score less than or equal to 6 on baseline CT.
- Patients with occlusions in multiple vascular territories.
- Evidence of intracranial tumor (except for small meningiomas)
Who the study is looking for
- A new disabling focal neurological deficit compatible with acute cerebral ischemia.
- Any age. Informed consent obtained from the patient or representative.
- NIHSS score ≥ 6.
- Pre-existing functional clinical status less than or equal to 2 according to the mRS clinical scale.
- Maximum time of 24 hours from symptom onset to arterial puncture. • TICI 0-1 in the diagnosed TICA (terminal internal carotid artery) , MCA (middle cerebral artery), and BA( basilar artery confirmed by angioCT and angiography).
- ASPECTs score on baseline CT greater than or equal to 6.
- In cases where it is indicated, prior intravenous fibrinolysis will be administered according to the protocols of each center.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Alfried Krupp Hospital Ruettenscheid Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
| Hospital Universitario de Cruces Coordinator of this site? Confirm its status | Barakaldo | Spain | Recruiting |
| Hospital Universitario Central De Asturias Coordinator of this site? Confirm its status | Oviedo | Spain | Recruiting |
| Hospital Clínico Universitario de Valladolid Coordinator of this site? Confirm its status | Valladolid | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.