NCT05930821Active, not recruiting
Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 27 Feb 2025
Brief summary (registry, in English)
The overall objective of the proposed randomized controlled (RCT) is to determine the feasibility and efficacy of a 16-week theory-based, remotely-delivered, combined exercise (aerobic and resistance) training intervention for improving cognitive and physical function in older adults (50+ years) with multiple sclerosis (MS) who have mild-to-moderate cognitive and walking impairment. Participants (N=50) will be randomly assigned into exercise training (combined aerobic and resistance exercise) condition or active control (flexibility and stretching) condition. The 16-week intervention will be delivered and monitored remotely within a participant's home/community and supported by Zoom-based chats guided by social cognitive theory (SCT) via a behavioral coach. Participants will receive training materials (e.g., prescriptive manual and exercise equipment), one-on-one coaching, action-planning via calendars, self-monitoring via logs, and SCT-based newsletters. It is hypothesized that the home-based exercise intervention will yield beneficial effects on cognition, mobility, physical activity, and vascular function compared with an active control condition (flexibility and stretching intervention), and these improvements will be sustained during a 16-week follow-up period.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 51 (actual)
- First submitted
- 7 Jun 2023
- Start date
- 5 Jul 2023
- Primary completion date
- 11 Feb 2025
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Multiple sclerosis
- NCT number
- NCT05930821
What you commit to
- Study type: Interventional
- Participants enrolled: 51
- From 5 Jul 2023 to the primary completion date, 11 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals diagnosed with other neurological conditions or cardiovascular diseases
Other
- Individuals not meeting above inclusion criteria
- Individuals with moderate to high risk for contraindications of possible injury or death when undertaking strenuous or maximal exercise (PARQ)
Who the study is looking for
- Age 50 years or older
- Diagnosis of MS
- Relapse-free for the past 30 days
- Internet and e-mail access
- Ability to travel to the laboratory (for testing only)
- Willingness to complete the assessments and be randomized
- Ambulatory with or without a single-point assistive device
- Mild-to-moderate cognitive impairment (TICS-M; MSNQ)
- Walking impairment (MSWS-12)
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Illinois at Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.