A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

Prior treatment

• Have had steroid joint injections within 90 days of screening.
• Have a self-reported or documented change in body weight \>5 kg (11 pounds) within 90 days prior to screening.
• Have been taking weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
• Have a prior or planned surgical treatment for obesity.

Other illness

• Have joint disease other than osteoarthritis.
• Have diabetes mellitus.

Other

• Have had other joint injections and procedures within 6 months of screening.

• Have a body mass index (BMI) ≥27 kilogram/kg/m² at screening.
• Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight.
• Have index knee pain for \>12 weeks prior to screening, and presence of index knee pain for \>15 days over the previous month.
• Have knee X-ray with moderate radiographic changes (Kellgren-Lawrence Grade 2 or 3) per central reading at screening.
• Currently meets American College of Rheumatology (ACR) Criteria (clinical and radiological) for OA.