NCT05931419Recruiting
High-Risk prostatE Cancer radiatiOn Versus surgERy
High-Risk prostatE Cancer radiatiOn Versus surgERy (RECOVER)
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
Prospective cohort study comparing robot-assisted radical prostatectomy and external beam radiotherapy +/- androgen deprivation therapy for high-risk non-metastatic prostate cancer in terms of health-related quality of life, functional outcomes, cost-effectiveness, progression-free survival and distant metastasis-free survival.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 837 (estimated)
- First submitted
- 26 Apr 2023
- Start date
- 16 Feb 2023
- Primary completion date
- 30 Sept 2029
- Lead sponsor
- Comprehensive Cancer Centre The Netherlands
- Diseases
- Prostate cancer
- NCT number
- NCT05931419
What you commit to
- Study type: Observational
- Planned participants: 837
- From 16 Feb 2023 to the primary completion date, 30 Sept 2029
- 28 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with Androgen Receptor Targeted Agents (ARTA) as part of the initial treatment plan
Other
- Histological types other than adenocarcinoma
- Diagnosis and/or treatment in a hospital abroad
Who the study is looking for
- Histologically confirmed de novo non-metastatic high-risk prostate cancer.
- cT3a-bN0M0, according to the 8th edition of the Tumour, Node, Metastasis (TNM) classification, with the exception that clinical T-stage will be based on digital rectal examination and magnetic resonance imaging (the highest stage will be used) and/or
- International Society of Urological Pathology (ISUP) grade ≥4 and/or
- Prostate-Specific Antigen (PSA) value at diagnosis greater than 20 ng/mL
- Fit for treatment with either RARP or EBRT +/- ADT (WHO performance status 0-1)
- Living in the Netherlands
- Able to read and understand the Dutch language
Age in the registry: 50 years to 75 years · Sex: Male · Does not accept healthy volunteers
Sites (28)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Noordwest Ziekenhuisgroep Coordinator of this site? Confirm its status | Alkmaar | Netherlands | Recruiting |
| OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Amsterdam UMC Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| BovenIJ Ziekenhuis Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Antoni van Leeuwenhoek Ziekenhuis Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Wilhelmina ziekenhuis Coordinator of this site? Confirm its status | Assen | Netherlands | Recruiting |
| Rode Kruis Ziekenhuis Coordinator of this site? Confirm its status | Beverwijk | Netherlands | Recruiting |
| Albert Schweitzer Ziekenhuis Coordinator of this site? Confirm its status | Dordrecht | Netherlands | Recruiting |
| Catharina Ziekenhuis Coordinator of this site? Confirm its status | Eindhoven | Netherlands | Completed |
| Admiraal de Ruyter Ziekenhuis Coordinator of this site? Confirm its status | Goes | Netherlands | Recruiting |
| Martini Ziekenhuis Coordinator of this site? Confirm its status | Groningen | Netherlands | Recruiting |
| Universitair Medisch Centrum Groningen Coordinator of this site? Confirm its status | Groningen | Netherlands | Recruiting |
| Saxenburgh Medisch Centrum Coordinator of this site? Confirm its status | Hardenberg | Netherlands | Recruiting |
| St.Jansdal Coordinator of this site? Confirm its status | Harderwijk | Netherlands | Recruiting |
| Spaarne Gasthuis Coordinator of this site? Confirm its status | Hoofddorp | Netherlands | Recruiting |
| Treant Coordinator of this site? Confirm its status | Hoogeveen | Netherlands | Recruiting |
| Dijklander Ziekenhuis Coordinator of this site? Confirm its status | Hoorn | Netherlands | Recruiting |
| Leids Universitair Medisch Centrum Coordinator of this site? Confirm its status | Leiden | Netherlands | Recruiting |
| Radboudumc Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Completed |
| Canisius Wilhelmina Ziekenhuis Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Completed |
| Franciscus Gasthuis & Vlietland Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Recruiting |
| Maasstad Ziekenhuis Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Recruiting |
| Erasmus Medisch Centrum Rotterdam Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Recruiting |
| Ommelander Ziekenhuis Coordinator of this site? Confirm its status | Scheemda | Netherlands | Recruiting |
| Haaglanden Medisch Centrum Coordinator of this site? Confirm its status | The Hague | Netherlands | Recruiting |
| Verbeeten Instituut Coordinator of this site? Confirm its status | Tilburg | Netherlands | Recruiting |
| Maxima Medisch Centrum Coordinator of this site? Confirm its status | Veldhoven | Netherlands | Completed |
| Zaans Medisch Centrum Coordinator of this site? Confirm its status | Zaandam | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.