NCT05932069Recruiting
Active AMD Study to Improve Function in Veterans
The Active AMD Study to Improve Function in Veterans With Age Related Macular Degeneration
Source: ClinicalTrials.gov · Last updated 23 Feb 2026
Brief summary (registry, in English)
Age Related Macular Degeneration (AMD) is the leading cause of vision loss among Veterans aged 50 years and older. AMD also adversely affects mortality, physical and cognitive functioning, and activities of daily living. These debilitations negatively impact quality of life for US Veterans. Unfortunately, there are no cures and few treatments. With the increase in the aging Veteran population and the increasing prevalence of AMD, it is imperative to identify and implement strategies to limit the functional burden of AMD. To address this growing challenge, the investigators propose to test the impact of a proven exercise intervention, stationary bicycling (spinning), on visual and non-visual negative health outcomes in AMD. The work in several retinal degeneration mouse models shows that aerobic exercise significantly preserves retinal morphology and function and visual acuity. Even more exciting, the investigators' preliminary work with older Veterans with and without AMD suggests that spin cycling modestly but significantly benefits visual acuity in aged Veterans. Based on this work, the investigators propose to implement a 6-month synchronous, online group spin cycling program for Veterans with AMD, evaluating effects on physical, cognitive, and visual outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 25 May 2023
- Start date
- 1 Mar 2024
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Macular degeneration
- NCT number
- NCT05932069
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 1 Mar 2024 to the primary completion date, 31 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other, non-AMD, visual impairments. Potential participants with major psychiatric disorder (including but not limited to psychosis, major depression, bipolar disorder) by history will be excluded as well as individuals with current alcohol or substance use disorder.
- Additionally, individuals with cardiovascular disease and or history of myocardial infarction will not be included.
Who the study is looking for
- The investigators will recruit Veterans with a diagnosis of intermediate stage AMD in at least one eye, aged 65-89, willing and able to cooperate with assessments and interventions.
- Eligible participants will be quantified \> 26 on the Montreal Cognitive Assessment (MoCA) to meet the criteria for cognitively intact.
- Participants will be free from diseases affecting cognition or ability to engage in aerobic exercise (including but not limited to chronic heart, liver, or kidney disease) and from diseases/injuries directly affecting brain functions (including but not limited to significant closed head injury, open intracranial wounds, stroke, epilepsy, degenerative diseases of the nervous system).
- Eligible participants will be required to have stable internet access in their home.
- All subjects will speak English as a primary language and will have graduated high school so that behavioral/cognitive measures reflect effects of age, AMD, and/or aerobic exercise and not the effects of familiarity with English or lack of education.
Age in the registry: 65 years to 89 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atlanta VA Medical and Rehab Center, Decatur, GA Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.