NCT05933681Active, not recruiting
Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- First submitted
- 27 Jun 2023
- Start date
- Jul 2023
- Primary completion date
- Aug 2027
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Parkinson disease
- NCT number
- NCT05933681
What you commit to
- Study type: Interventional
- Planned participants: 160
- From Jul 2023 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Age less than 18
Other
- Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)
Who the study is looking for
- Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1)
- Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
- Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
- Age at least 18
- Able to participate in intraoperative testing
- English speaking
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.