NCT05934409Recruiting
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Improved Adipose Tissue Storage of Dietary Fatty Acids as a New Mechanism for the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery. All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 8 Jun 2023
- Start date
- 1 Nov 2023
- Primary completion date
- 31 Jan 2028
- Lead sponsor
- Université de Sherbrooke
- Diseases
- Type 2 diabetes
- NCT number
- NCT05934409
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Nov 2023 to the primary completion date, 31 Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with an oral contraceptive;
- Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects;
- Having participated to a research study with exposure to radiation in the last two years before the start of the study;
Other illness
- Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions;
- Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension;
- A Diabetes Remission (DiaRem) score \>8 (low probability of T2D remission);
- Being allergic to eggs
Other
- Smoking or consumption of more than 2 alcoholic beverages per day;
- Any contraindication to MRI;
- Pregnant or breastfeeding women;
- Patients weighing more than 200 kg to respect the weight and gantry limit of our MRI and PET/CT scanners.
Who the study is looking for
- Aged 18 to 65
- BMI 35 kg/m2
- Diagnosed T2D - according to Diabetes Canada diagnostics criteria.
- Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria.
- Women with a negative serum pregnancy test.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre de recherche du CHUS Coordinator of this site? Confirm its status | Sherbrooke | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.