NCT05935670Completed
Passive Limb Movement Study
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. No studies have examined how femoral blood flow responds to both passive leg movement, a measure of microvascular function, as well as active leg contractions, a measure of the hyperemic response to exercise. Leg muscles with a reduced blood flow response to movement could be associated with decreased neuromuscular function, such as leg strength and fatigue. Preliminary data showing a single bout of ischemic conditioning may improve vascular function and muscle activation in healthy adults and individuals post-stroke. Therefore, the investigators want to examine if ischemic conditioning will also improve the blood flow response to passive leg movements as well as during single leg active contractions.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 44 (actual)
- First submitted
- 22 Jun 2023
- Start date
- 13 Jun 2023
- Primary completion date
- 19 Dec 2025
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Stroke
- NCT number
- NCT05935670
What you commit to
- Study type: Interventional
- Participants enrolled: 44
- From 13 Jun 2023 to the primary completion date, 19 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- All Groups
- Unable to stand from chair and walk 10 meters without physical assistance from another person (able to use assistive device).
- History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
- Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization)
- Low back or hip pain that limits lower extremity motor testing.
- History of head trauma or concussion within the past 6 months
- Comorbid neurological disorder
- Peripheral vascular disease
- Myocardial infarction in the previous year
- Condition where fatiguing contractions or resisted leg contractions are contraindicated
- Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
- Pregnancy or breastfeeding.
- Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator
Other illness
- CON and CONyoung
- History of Stroke
Who the study is looking for
- Individuals Post-Stroke
- 18 - 85 years of age
- Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
- Able to give informed consent and follow 2-step command.
- English Speaking
- Age- and Sex-Matched Controls (CON)
- Matched to age of individual post- stroke ± 5 years.
- Matched to sex of individual post-stroke
- Able to give informed consent and follow 2-step command.
- English Speaking
- Young Healthy Adults (CONyoung)
- Age 18-30 years old
- Able to give informed consent and follow 2-step command.
- English Speaking
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.