NCT05938127Terminated
Impact of Respiratory Training in Lymphoma Survivors
The Impact of Inspiratory Muscle Strength Training and Personalized Exercise Prescription on Metabolism, Cardiovascular Function, and Cardiorespiratory Fitness in Lymphoma Survivors
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
High-resistance inspiratory muscle strength training (IMST) is a time-efficient (~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.
- Status (registry)
- Terminated
- Study type
- Interventional
- Enrollment
- 1 (actual)
- First submitted
- 30 Jun 2023
- Start date
- 16 Sept 2024
- Primary completion date
- 9 Dec 2024
- Lead sponsor
- University of Colorado, Denver
- Diseases
- Hodgkin lymphoma
- NCT number
- NCT05938127
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- oSecond active cancer diagnosis
- oPlanned active cancer treatment or change in current treatment in the next 6 months
- Severe obesity (BMI >; 40 kg/m2) or underweight (BMI <18.5 kg/m2)
- Unstable weight (>; 3 kg change in body mass in last 3 months)
- Significant metabolic disorder (e.g. diabetes type II)
- Uncontrolled thyroid disease
- Recent changes in hypertensive medication (within last 3 months)
- Any medical condition that would impact the safety of, or participation in, an exercise program, including:
- Significant pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
- Known cardiovascular disease, significant hypertension (>180/120), or a recent cardiac event (within past 6 months)
- Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
- Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
Who the study is looking for
- Age 18 - 80
- Primary cancer diagnosis of lymphoma
- Able and willing to participate in a supervised exercise program at the Anschutz Health and Wellness Center
- Provides a signed physician exercise clearance form
- SBP > 120 mmHg
- Completion of curative cancer treatment over 12 months prior (individuals on maintenance therapy will be included)
- Possession of a smartphone compatible with the IMST training application (available on both Android and Apple).
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Anschutz Health and Wellness Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| University of Colorado Cancer Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.