NCT05940766Recruiting
Swiss 2024 Continous Fever Monitoring in Pediatric Oncology Patients
Swiss 2024 Fever Monitoring Study: An Double-blinded, Randomized Controlled Multiple Crossover Superiority Trial on Continuous Fever Monitoring in Paediatric Patients With Cancer at Risk for Fever in Neutropenia
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
In children and adolescents undergoing chemotherapy for cancer, fever in neutropenia (FN) is the most frequent potentially lethal complication of chemotherapy for cancer. Emergency hospitalization and empirical treatment with i.v. broad-spectrum antibiotics have reduced lethality from \>50% in certain high risk situations to \<1%. Fever without neutropenia is a further complication requiring emergency evaluation and often emergency treatment. Continuous monitoring of fever leads to earlier fever detection compared to the usual discrete fever measurements performed only for clinical reasons. Earlier detection of fever leads to earlier assessment and treatment and thus can reduce the risk of complications. This study primarily aims to assess, in pediatric patients undergoing chemotherapy for cancer, the efficacy of automated fever alerts resulting from continuous fever monitoring (CFM) using a wearable device (WD), measured by the duration of intravenous antibiotics (i.v. AB) given for any cause.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 250 (estimated)
- First submitted
- 8 Jun 2023
- Start date
- 1 Feb 2025
- Primary completion date
- 31 May 2028
- Lead sponsor
- Insel Gruppe AG, University Hospital Bern
- Diseases
- Childhood cancers
- NCT number
- NCT05940766
What you commit to
- Study type: Interventional
- Planned participants: 250
- From 1 Feb 2025 to the primary completion date, 31 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Local skin disease prohibiting wearing of the WD
Other
- Neonates \<1 months
- Denied written informed consent from patients and/or parents
- Inclusion of vulnerable participants mandatory as vital signs and FN episodes differ significantly in children and adults
Who the study is looking for
- Chemotherapy treatment because of any malignancy expected to last ≥2 months at time of recruitment for myelosuppressive therapy, or at least 1 cycle of myeloablative chemotherapy followed by hematopoietic stem cell transplantation
- Age ≥1 month and \<18 years at time of recruitment
- Written informed consent from patients and/or parents
Age in the registry: 1 month to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Childrens' Clinc Bern, Inselspital Bern Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.