NCT05942404Completed
Investigation of the Effect of Preoperative Bowel Cleansing on Postoperative Cognitive Impairment
Investigation of the Effect of Preoperative Bowel Cleansing on Lipopolysaccharide Binding Protein, Brain-Derived Neurotrophic Factor and Tau Protein Levels and Their Relationship With Postoperative Cognitive Impairment
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
Cognitive impairment has been reported up to 54 % after colorectal surgeries. Mechanical bowel cleansing means that a system called the second brain in the body, which includes a wide variety of genetic and neuronal structures, is damaged. 100 trillion microorganisms live in the human body. The largest contact area with the external environment in the body, is the gastrointestinal mucosa. Microorganisms in the gut contain 100 times more genes than the human genome. The GI mucosa contains more than 500 million neurons called the enteric nervous system. MBP is an application that disrupts the microbiota structure and causes dehydration and electrolyte imbalance. While the most serious indication for MBP is seen as infection and health of anastomosis, recent studies say that this is not the case, even that the deterioration of the microbiota content damages the mucosal barrier, predisposes to inflammation with the removal of beneficial microorganisms and impairs wound healing. 84 patients will be included in the study, divided into two groups. In each group, blood will be drawn to measure the levels of biomarkers determined before surgery and bowel cleansing, on the 15th postoperative day and on the 90th day. Simultaneously, psychometric tests will be performed to assess cognitive impairment.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 84 (actual)
- First submitted
- 14 Jun 2023
- Start date
- 22 Oct 2023
- Primary completion date
- 21 Jul 2024
- Lead sponsor
- TC Erciyes University
- NCT number
- NCT05942404
What you commit to
- Study type: Interventional
- Participants enrolled: 84
- From 22 Oct 2023 to the primary completion date, 21 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who require emergency surgery
- Patients who take long-term steroid therapy (7 days or more)
- Patients receiving immunosuppressive therapy
Other illness
- Patients with cerebrovascular disease
- Patients with neurodegenerative disease
- Patients with severe and moderate dementia (MoCA test score 21 and below)
- Patients with severe hearing and vision impairment
Other
- Patients with inflammatory bowel
- Patients who have had repetitive surgeries
- Patients with a mini mental test below 24
- Patients using antibiotics and probiotics
Who the study is looking for
- Patients who agreed to participate in the study
- Patients undergoing elective colorectal surgery
- Patients who can read and write
- Patients whose hearing and sight are suitable for communication
- Patients whose general sociocultural status is sufficient to perform psychometric tests.
Age in the registry: 45 years to 80 years · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Erciyes University Coordinator of this site? Confirm its status | Melikgazi | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.