NCT05947045Recruiting
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
Source: ClinicalTrials.gov · Last updated 17 Jun 2026
Brief summary (registry, in English)
The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors. To achieve this goal, the investigators plan to study children undergoing radiotherapy for brain tumors randomly assigned to cognitive training administered via an iPad or virtual reality. Both groups will also participate in cognitive testing and exams using functional near infrared spectroscopy (fNIRS) pre- and post-intervention. The questions to be investigated are: 1. Will cognitive training via virtual reality be feasible and acceptable for children undergoing radiotherapy for brain tumors as indicated by participation rates, adherence and frequency of side effects? 2. Will cognitive training via virtual reality provide neurocognitive benefits? 3. Will there be predictable changes in brain activity as measured by neuroimaging? Findings from this study will be used to develop a larger, definitive trial with direct potential to improve cognitive outcomes for children treated for cancer using a safe and effective alternative to desktop- or laptop-based computerized cognitive interventions with great promise for improving quality of life.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 7 Jun 2023
- Start date
- 22 Jun 2023
- Primary completion date
- Mar 2027
- Lead sponsor
- St. Jude Children's Research Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT05947045
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 22 Jun 2023 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Need for general anesthesia during radiation therapy (note: can participate if only sedated for simulation/planning but not daily treatment)
Other illness
- Significant impairment in global intellectual functioning (estimated or full scale IQ \< 70 based on standardized testing routinely conducted on primary treatment protocols or as part of the New Oncology Program in Psychology \[NOPP\])
- History of significant neurological disease preceding BT diagnosis including stroke or head injury with loss of consciousness
- Major sensory or motor impairment that would preclude valid cognitive testing secondary to inability to complete study procedures (e.g., blindness, paresis, poorly controlled seizures/photosensitive epilepsy, inadequate balance to sit or stand unassisted to complete cognitive training)
- Psychiatric condition that would preclude or take precedence over study participation (e.g. active psychosis, suicidal ideation)
Who the study is looking for
- Initiating radiotherapy for a BT
- Between 8-22 years of age at the time of enrollment
- English or Spanish as the primary language
- Research participant and one parent willing to participate and provide consent/assent according to institutional guidelines
- Participant willing to take part in required aspects of Cogmed training
Age in the registry: 8 years to 22 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.