NCT05947318Completed
Effect of tACS on the Recovery of Motor Control of the Upper Limb and Cerebral Connectivity in Chronic Stroke Patients
Effect of Transcranial Alternating Current Stimulation on the Recovery of Motor Control of the Upper Limb and Cerebral Connectivity in Chronic-stage Stroke Patients
Source: ClinicalTrials.gov · Last updated 29 Apr 2025
Brief summary (registry, in English)
This project seeks to evaluate the effect of transcranial alternating current stimulation (tACS) on the recovery of motor control of the upper limb and associated neuronal synchrony during a 14-sessions (5-week) rehabilitation program for adult patients with diagnosis of stroke at chronic stage. Specifically, the stimulation on Gamma ranges, because the evidence available so far allows us to propose that the tACS in the Gamma range (around 70 Hz) facilitates motor execution. For this purpose, the experimental approach involves active (70 Hz in Gamma rhythm and 7 Hz, Theta rhythm) and sham tACS together with an analytical and integrated motor training with a double-blind and randomized design. Our hypothesis is that Gamma frequency tACS restores neuronal synchrony in Beta range, which enhances the upper limb motor recovery associated with a training program. Using specific motor control parameters, clinical scales and electroencephalography, the immediate and long-term (3 months after finished the training) behavioral and neurophysiological effect of this new neurostimulation paradigm (tACS plus training) for motor rehabilitation of stroke will be established.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 59 (actual)
- First submitted
- 12 Jun 2023
- Start date
- 2 May 2023
- Primary completion date
- 7 Apr 2025
- Lead sponsor
- Universidad Metropolitana de Ciencias de la Educacion
- Diseases
- Stroke
- NCT number
- NCT05947318
What you commit to
- Study type: Interventional
- Participants enrolled: 59
- From 2 May 2023 to the primary completion date, 7 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have a cerebellar stroke or ataxia
- Have some medical condition contraindicated for tACS (epilepsy, pacemaker, prosthesis between others)
- Have post-stroke epilepsy
- Have another neurological condition that leads to upper extremity sequelae
Other
- Limited passive range of motion in the elbow (less than 45º in flexo-extension plane)
- Limited passive range of motion in the wrist (less than 40º in flexo-extension plane)
- Limited passive range of motion in the shoulder (less than 70º in flexo-extension plane)
- Have a normal performance in the clinical test
Who the study is looking for
- Diagnosis of unilateral stroke at chronic stage (6 months or more)
- Upper Extremity -Fugl Meyer \> 10
- Wrist extensors strength of the paretic limb of 2 or more in the Medical Research Council (MRC) scale
- Active shoulder movement (flexion or abduction) of 30º or more
- Be able to follow the instructions necessary to achieve the training protocol
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro de Habilidades Clínicas - Universidad Metropolitana de Ciencias de la Educación Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.