NCT05948657Recruiting
Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr
ESCAPE - Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 20 Jun 2023
- Start date
- 26 Feb 2024
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Weill Medical College of Cornell University
- Diseases
- Prostate cancer
- NCT number
- NCT05948657
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 26 Feb 2024 to the primary completion date, 31 Dec 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of prior treatment for prostate cancer.
Other illness
- History of systemic therapy for prostate cancer.
- Initial diagnosis of prostate cancer greater than 15 months.
Other
- Inability to undergo transrectal ultrasound.
- Life expectancy less than 10 years.
- Not interested in pursuing active surveillance.
Who the study is looking for
- Males aged ≥ 18.
- Histologically confirmed low or favorable intermediate risk prostate cancer per NCCN guidelines. (Note: Grade Group 2 must have 20% or less involvement in every core and no presence of cribiform or intraductal carcinoma).
- PSA \< 20 ng/ml.
- Ability to undergo yearly PSMA-PET CT.
- Ability to undergo yearly prostate mpMRI.
- Ability to undergo transrectal or transperineal template and fusion prostate biopsy.
- Willingness to undergo yearly prostate biopsies.
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UH Cleveland Medical Center Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
| UCLA Coordinator of this site? Confirm its status | Los Angeles | United States | Not yet recruiting |
| Weill Cornell Medicine-New York Presbyterian Hospital Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| UCSF Coordinator of this site? Confirm its status | San Francisco | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.