NCT05950607Recruiting
Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0 (TRAIN-AD 2.0)
Source: ClinicalTrials.gov · Last updated 6 Jan 2026
Brief summary (registry, in English)
The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 750 (estimated)
- First submitted
- 10 Jul 2023
- Start date
- 13 Nov 2023
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- Hebrew SeniorLife
- Diseases
- Alzheimer disease
- NCT number
- NCT05950607
What you commit to
- Study type: Interventional
- Planned participants: 750
- From 13 Nov 2023 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Does not have diagnosis of dementia
Age
- Less than 60 years of age
Other
- Living in nursing home for less than 90 days
- Does not meet CFS \>1 score
Who the study is looking for
- Age \> 60
- A diagnosis of dementia (any type)
- Cognitive Functional Scale (CFS) \> 1
- NH length of stay \>90 days
- The CFS score categorizes cognitive impairment status based on data in the electronic health record into: 1. None, 2. Mild, 3. Moderate, and 4. Severe (advanced). For the primary outcome, the analysis will be restricted to residents with a CFS score of 3 or 4.
Age in the registry: 60 years to 106 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hebrew SeniorLife Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.