NCT05955196Recruiting
Test of CD47-SIRPα Inhibitors on the Immune Microenvironment Colon Cancer
Source: ClinicalTrials.gov · Last updated 9 Oct 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Our goal is to create novel CD47-SIRPα inhibitors using small molecules to reverse TAM-mediated immune suppression and restore anti-tumor immunity in CRCs. Our program uses structure-based drug design to create selective and potent small molecule inhibitors of SIRPα-CD47 to target the tumor microenvironment with greater efficacy and lower toxicity than CD47-targeting antibodies. . In order to study the activity of CD47-SIRPα inhibitors on the immune microenvironment of tumors, we propose to use organoids derived from biopsies of patients with colon cancer. Tumoroids preserve the patient's tumor stroma (including myeloid cells) and provide an accurate in vitro model of complex tumor immune interaction for the evaluation of immunotherapies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 115 (estimated)
- First submitted
- 27 Jan 2023
- Start date
- 9 Jan 2023
- Primary completion date
- 9 Jan 2025
- Lead sponsor
- Institut Paoli-Calmettes
- Diseases
- Colorectal cancer
- NCT number
- NCT05955196
What you commit to
- Study type: Observational
- Planned participants: 115
- From 9 Jan 2023 to the primary completion date, 9 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patient who had emergency colon cancer surgery
Other
- Person in an emergency situation or unable to express their consent.
- Adult subject to a legal protection measure (adult under guardianship, curatorship or safeguard of justice),
- Patient unable to submit to the medical follow-up of the trial for geographical, social or psychological reasons
Who the study is looking for
- Patient over 18 years old
- Patient who has signed a consent to participate;
- Patient with metastatic or non-metastatic colon cancer, or recurrence of colon cancer for whom excision surgery has been proposed;
- Patient affiliated to a social security scheme, or beneficiary of such a scheme
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institut Paoli-Calmettes Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.