NCT05963022CompletedPhase 3
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)
A Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Tirzepatide Monotherapy Compared With Placebo in Chinese Participants With Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 21 Oct 2025
Brief summary (registry, in English)
The main purpose of this study is to investigate the efficacy and safety of Tirzepatide monotherapy in Chinese participants with Type 2 Diabetes.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 206 (actual)
- First submitted
- 19 Jul 2023
- Start date
- 21 Aug 2023
- Primary completion date
- 9 Oct 2024
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Type 2 diabetes
- NCT number
- NCT05963022
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 206
- From 21 Aug 2023 to the primary completion date, 9 Oct 2024
- 28 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a history of chronic or acute pancreatitis any time prior to study entry
- Are currently receiving treatment for diabetic retinopathy and/or macular edema
- Use of insulin 1-year preceding screening and between screening and baseline; use of any antihyperglycemic medication 90 days preceding screening and between screening and baseline.
Other illness
- Have Type 1 Diabetes
- Have a history of ketoacidosis or hyperosmolar state/coma
- Have a history of New York Heart Association Functional Classification IV congestive heart failure (CHF)
- Have acute or chronic hepatitis including a history of autoimmune hepatitis
Who the study is looking for
- Have Type 2 Diabetes
- Have HbA1c ≥7.0% (≥53 mmol/mol) to ≤9.5% (≤80 mmol/mol) despite diet and exercise treatment
- Are of stable weight 5%) during the 90 days preceding screening and agree not to initiate a diet and/or exercise program during the study with the intent of reducing body weight other than the lifestyle and dietary measures for diabetes treatment
- Have Body Mass Index (BMI) ≥23.0 kilogram per square meter (kg/m²)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (28)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chinese PLA General Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The First People's Hospital of Changde City Coordinator of this site? Confirm its status | Changde | China | Unknown status |
| West China Hospital of Sichuan University Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| Chengdu Fifth People's Hospital Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| Dalian University - The Affiliated Zhongshan Hospital Coordinator of this site? Confirm its status | Dalian | China | Unknown status |
| Dalian Municipal Central Hospital Affiliated of Dalian Medical University Coordinator of this site? Confirm its status | Dalian | China | Unknown status |
| Shunde Hospital of Southern Medical Univesity Coordinator of this site? Confirm its status | Foshan | China | Unknown status |
| Hainan General Hospital Coordinator of this site? Confirm its status | Haikou | China | Unknown status |
| The Fourth Affiliated Hospital of Harbin Medical University Coordinator of this site? Confirm its status | Harbin | China | Unknown status |
| Huizhou Municipal Central Hospital Coordinator of this site? Confirm its status | Huizhou | China | Unknown status |
| Huzhou Central Hospital Coordinator of this site? Confirm its status | Huzhou | China | Unknown status |
| Jinan Central Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Panjin Liaoyou Baoshihua Hospital Coordinator of this site? Confirm its status | Liaoyou | China | Unknown status |
| The First Affiliated Hospital of Henan University of Science &Technology Coordinator of this site? Confirm its status | Luoyang Shi | China | Unknown status |
| Nanjing First Hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| The Second Affiliated Hospital of Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| Nanjing Medical University - Nanjing Jiangning Hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| The First Affiliated Hospital of Nanyang Medical College Coordinator of this site? Confirm its status | Nanyang | China | Unknown status |
| JiangXi PingXiang People's Hospital Coordinator of this site? Confirm its status | Pingxiang | China | Unknown status |
| Jiading District Central Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Pudong New Area People's Hospital Shanghai Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| The First Affiliated Hospital of Soochow University Coordinator of this site? Confirm its status | Suzhou | China | Unknown status |
| Tianjin Medical University General Hospital Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
| The First Affiliated Hospital of Xi'an Medical University Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Yichang Central People's Hospital Coordinator of this site? Confirm its status | Yichang | China | Unknown status |
| The Second Affiliated Hospital of Zhengzhou University Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
| Affiliated Hospital of Jiangsu University Coordinator of this site? Confirm its status | Zhenjiang | China | Unknown status |
| Zunyi First People's Hospital Coordinator of this site? Confirm its status | Zunyi | China | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.