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NCT05963022CompletedPhase 3

A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)

A Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Tirzepatide Monotherapy Compared With Placebo in Chinese Participants With Type 2 Diabetes

Source: ClinicalTrials.gov · Last updated 21 Oct 2025

Brief summary (registry, in English)

The main purpose of this study is to investigate the efficacy and safety of Tirzepatide monotherapy in Chinese participants with Type 2 Diabetes.

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
206 (actual)
First submitted
19 Jul 2023
Start date
21 Aug 2023
Primary completion date
9 Oct 2024
Lead sponsor
Eli Lilly and Company
NCT number
NCT05963022

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 206
  • From 21 Aug 2023 to the primary completion date, 9 Oct 2024
  • 28 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Have a history of chronic or acute pancreatitis any time prior to study entry
  • Are currently receiving treatment for diabetic retinopathy and/or macular edema
  • Use of insulin 1-year preceding screening and between screening and baseline; use of any antihyperglycemic medication 90 days preceding screening and between screening and baseline.

Other illness

  • Have Type 1 Diabetes
  • Have a history of ketoacidosis or hyperosmolar state/coma
  • Have a history of New York Heart Association Functional Classification IV congestive heart failure (CHF)
  • Have acute or chronic hepatitis including a history of autoimmune hepatitis

Who the study is looking for

  • Have Type 2 Diabetes
  • Have HbA1c ≥7.0% (≥53 mmol/mol) to ≤9.5% (≤80 mmol/mol) despite diet and exercise treatment
  • Are of stable weight 5%) during the 90 days preceding screening and agree not to initiate a diet and/or exercise program during the study with the intent of reducing body weight other than the lifestyle and dietary measures for diabetes treatment
  • Have Body Mass Index (BMI) ≥23.0 kilogram per square meter (kg/m²)

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (28)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Chinese PLA General Hospital
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BeijingChinaUnknown status
The First People's Hospital of Changde City
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ChangdeChinaUnknown status
West China Hospital of Sichuan University
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ChengduChinaUnknown status
Chengdu Fifth People's Hospital
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ChengduChinaUnknown status
Dalian University - The Affiliated Zhongshan Hospital
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DalianChinaUnknown status
Dalian Municipal Central Hospital Affiliated of Dalian Medical University
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DalianChinaUnknown status
Shunde Hospital of Southern Medical Univesity
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FoshanChinaUnknown status
Hainan General Hospital
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HaikouChinaUnknown status
The Fourth Affiliated Hospital of Harbin Medical University
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HarbinChinaUnknown status
Huizhou Municipal Central Hospital
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HuizhouChinaUnknown status
Huzhou Central Hospital
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HuzhouChinaUnknown status
Jinan Central Hospital
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JinanChinaUnknown status
Panjin Liaoyou Baoshihua Hospital
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LiaoyouChinaUnknown status
The First Affiliated Hospital of Henan University of Science &Technology
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Luoyang ShiChinaUnknown status
Nanjing First Hospital
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NanjingChinaUnknown status
The Second Affiliated Hospital of Nanjing Medical University
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NanjingChinaUnknown status
Nanjing Medical University - Nanjing Jiangning Hospital
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NanjingChinaUnknown status
The First Affiliated Hospital of Nanyang Medical College
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NanyangChinaUnknown status
JiangXi PingXiang People's Hospital
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PingxiangChinaUnknown status
Jiading District Central Hospital
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ShanghaiChinaUnknown status
Pudong New Area People's Hospital Shanghai
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ShanghaiChinaUnknown status
The First Affiliated Hospital of Soochow University
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SuzhouChinaUnknown status
Tianjin Medical University General Hospital
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TianjinChinaUnknown status
The First Affiliated Hospital of Xi'an Medical University
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Xi'anChinaUnknown status
Yichang Central People's Hospital
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YichangChinaUnknown status
The Second Affiliated Hospital of Zhengzhou University
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ZhengzhouChinaUnknown status
Affiliated Hospital of Jiangsu University
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ZhenjiangChinaUnknown status
Zunyi First People's Hospital
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ZunyiChinaUnknown status

Related publications

This page is information, not medical advice. Discuss any trial with your doctor.