NCT05965518Recruiting
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults With HIV
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 19 Jul 2023
- Start date
- 5 Feb 2024
- Primary completion date
- Dec 2028
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- HIV
- NCT number
- NCT05965518
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 5 Feb 2024 to the primary completion date, Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diagnosis of mitochondrial disease
- Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
- Chronic kidney disease
- Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
- Acute myocardial infarction identified by medical history and ECG
- Pulmonary disease requiring the use of supplemental oxygen
- Poorly controlled diabetes
Other
- Active substance abuse or factors preventing compliance or safety
- Neuropsychologically Intact
- Orthopedic problems that limit ability to perform exercise
- Simultaneous participation in another intervention trial
Who the study is looking for
- Age 50 years and older
- Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
- Neurocognitive Impairment (as assessed using the BRACE+
- Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
- Able to speak, read, and write in English
- Willingness to participate in all study procedures
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.