NCT05973331Active, not recruiting
Prospective Validation of an EHR-based Pancreatic Cancer Risk Model
Prospective Validation of an EHR-based Model to Predict Pancreatic Cancer Risk Using Multicenter US Data
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
The goal of this prospective observational cohort study is to validate a previously developed pancreatic cancer risk prediction algorith (the PRISM model) using electronic health records from the general population. The main questions it aims to answer are: * Will a pancreatic cancer risk model, developed on routine EHR data, reliably and accurately predict pancreatic cancer in real-time? * What is the average time from model deployment and risk prediction, to the date of pancreatic cancer development and what is the stage of pancreatic cancer at diagnosis? The risk model will be deployed on data from individuals eligible for the study. Each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 6134060 (actual)
- First submitted
- 17 Jul 2023
- Start date
- 21 Apr 2023
- Primary completion date
- 8 Jun 2026
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Diseases
- Pancreatic cancer
- NCT number
- NCT05973331
What you commit to
- Study type: Observational
- Participants enrolled: 6134060
- From 21 Apr 2023 to the primary completion date, 8 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Personal history of PDAC or current PDAC
Age
- Age below 40
- Notes on sampling method: no sampling was performed. All eligible individuals are included in this study.
Who the study is looking for
- Male and females age \>= 40 years from 44 US HCOs from the TriNetX platform
- at least 2 clinical encounters to the HCO, within the last year, before the study start date
Age in the registry: 40 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.