NCT05974111Completed
COAgulation Disorders in Ischaemic and Haemorrhagic Stroke
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with ischaemic and haemorrhagic stroke (including aneurysmal subarachnoid haemorraghe). Also the cross-talk between inflammation and thrombosis, so-called thrombo-inflammation is further investigated. As such the investigators aim to characterise the patient's coagulation profile before administration of any treatment. By assessing these pathways the investigators strive to detect specific markers to predict vital and functional outcome at 3 months in these patients. Finally the investigators may provide new pathophysiological insights in the course of disease following these events that can possibly improve future therapeutic strategies.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 379 (actual)
- First submitted
- 30 May 2023
- Start date
- 2 May 2023
- Primary completion date
- 2 Aug 2025
- Lead sponsor
- Ziekenhuis Oost-Limburg
- Diseases
- Stroke
- NCT number
- NCT05974111
What you commit to
- Study type: Observational
- Participants enrolled: 379
- From 2 May 2023 to the primary completion date, 2 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving treatment with interference on coagulation (pro / anti) before first sampling: in this group of patients the coagulation assessment at presentation will be excluded, further lab sampling is performed according to protocol.
Other illness
- Traumatic intracranial (subdural, subarachnoid, epidural haematoma) bleeding
- Patients categorized as having stroke mimic will be excluded from analysis afterwards
Other
- Refusal of participation by patient or legal representative
Who the study is looking for
- Presenting at the hospital with ischaemic stroke, haemorrhagic stroke, aneurysmal subarachnoid haemorrhage or any other type of non-traumatic, intracranial bleeding
- In patients with minor ischemic stroke (NIHSS \<= 4) only baseline lab sampling will be performed (T0 and T0B).
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ziekenhuis Oost-Limburg Coordinator of this site? Confirm its status | Genk | Belgium | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.