NCT05975541Recruiting
Susceptibility to Infectious Diseases in Obesity
Susceptibility to Infectious Diseases in Obesity: an Endocrine, Translational, Sociological Evaluation
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology". The gut microbiota is strictly interconnected with obesity and T2D playing also an important role in immune system regulation. Obesity and diabetes can lead to chronic inflammation, which results in the secretion of pro-inflammatory cytokines like IL-6, IL-1, and TNF-alpha, causing immune system alteration which predisposes patients with obesity and T2D to chronic infections. Therefore, the principal aim of the study is to investigate changes in gut microbiota composition between patients with chronic infections or not, so as to attribute to specific phyla the formation of the infections in these patients.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 12 Jul 2023
- Start date
- 1 Oct 2023
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT05975541
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 Oct 2023 to the primary completion date, 31 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- bariatric surgery
- Alcohol or drug abuse
- antibiotic therapy
Other illness
- psychological conditions that reduced the ability the comprehension of the study protocol
- patients with relapsing infections
Other
- subjects undergoing a diet-therapeutic regimen;
- subjects with the possibility of developing diabetic foot in the successive months
- pregnancy
- oncological and hematological pathologies
- Hypogonadism
- severe immunodepression
- vaccination in the last two weeks
Who the study is looking for
- age between 18-65 years
- ability to understand the study protocol
- obesity with BMI between 30-40 kg/m2
- affects by type II diabetes
- presence/absence of chronic infections
- the possibility of equality in the two groups (matched for sex, age, and therapies)
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Maggiore della Carità Hospital Coordinator of this site? Confirm its status | Novara | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.