NCT05977439Recruiting
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
A Multiphase Program of Multimodal Computational Modeling and Hybrid Interventions Including EEG-Synchronized Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy
Source: ClinicalTrials.gov · Last updated 21 Jul 2026
Brief summary (registry, in English)
In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation. The study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 29 Jun 2023
- Start date
- 1 Feb 2024
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Depression
- NCT number
- NCT05977439
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 1 Feb 2024 to the primary completion date, 1 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any current or past psychiatric diagnosis
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Substance use disorder (excluding nicotine or caffeine)
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Substance use disorder (excluding nicotine or caffeine)
- Any condition that would interfere with safe participation or completion of study procedures
Other
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Pregnancy or plans to become pregnant during study participation
- Inability to complete study procedures
- Studies 2, 3, and 4 (Participants With Depression)
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Current participation in another interventional clinical trial
- Pregnancy or plans to become pregnant during study participation
Who the study is looking for
- Age 18-65 years
- Medically and psychiatrically healthy with no history of psychiatric or neurological disorders
- English-speaking
- Capacity to provide informed consent
- Willingness and ability to complete study procedures
- Negative pregnancy test for participants of childbearing potential
- Age 18-65 years
- Current diagnosis of Major Depressive Disorder (MDD)
- Depression severity consistent with study criteria (e.g., HAM-D ≥17)
- No history of psychotic or bipolar disorders
- English-speaking
- Capacity to provide informed consent
- Willingness and ability to complete study procedures
- Negative pregnancy test for participants of childbearing potential
Criteria the registry did not label
- Study 1 (Healthy Participants)
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical Univeristy of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.