NCT05977881Completed
Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study
Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 493 (actual)
- First submitted
- 27 Jul 2023
- Start date
- 28 Jul 2023
- Primary completion date
- 1 May 2026
- Lead sponsor
- Johns Hopkins Bloomberg School of Public Health
- Diseases
- HIV
- NCT number
- NCT05977881
What you commit to
- Study type: Interventional
- Participants enrolled: 493
- From 28 Jul 2023 to the primary completion date, 1 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Determined to be too high or drunk or cognitively impaired, less than 18 years of age
Other
- unwilling to provide all required biological specimens (Phase 3 only)
- unwilling/unable to give consent
Who the study is looking for
- 18 years or older,
- self-reports having used illicit stimulants or opioids at least once in the past 3 months,
- self-reports being HIV negative
- reports injection drug use in the past 6 months OR reports at least one of the following indicators of sexual HIV risk exposure in the past 6 months:
- Sexually Transmitted Infection (STI) diagnosis in the past 6 months
- "Condom-less" vaginal or anal sex in the past 6 months
- Willing to provide a urine sample for urine drug screening of substances
- Willing to undergo rapid HIV testing
- Willing to undergo STI testing
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins School of Public Health Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.