NCT05981885Completed
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19 With Respiratory Impairment After Hospital Discharge
Source: ClinicalTrials.gov · Last updated 21 May 2024
Brief summary (registry, in English)
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection. Fibroblasts are involved in tissue remodeling and repair by creating scar-tissue (fibrosis) after tissue damage has occurred. The hypothesis is that this process of fibrosis is ongoing in patients with persistent complaints. To evaluate the roll of fibroblasts a new type of scan is used that is capable of imaging active fibroblasts, a 68Ga-FAPI PET/CT scan.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 18 (actual)
- First submitted
- 22 Jun 2023
- Start date
- 9 Jun 2022
- Primary completion date
- 21 Nov 2023
- Lead sponsor
- University Medical Center Groningen
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT05981885
What you commit to
- Study type: Observational
- Participants enrolled: 18
- From 9 Jun 2022 to the primary completion date, 21 Nov 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of claustrophobia or feeling of inability to tolerate supine position for the PET/CT scans.
- Severe or significant comorbidity, defined as COPD GOLD stage II or higher and/or known interstitial lung disease.
Other
- Inability or unwilling to give informed consent.
- Women who are pregnant or breastfeeding.
Who the study is looking for
- Male patients \>18 years and female patients \>20 years discharged from hospital after PCR-confirmed COVID-19 infection.
- Previous ICU or ward admission with high flow nasal oxygen (HFNO) or mechanical ventilation.
- Persistent respiratory complaints (shortness of breath) at least 3 months after hospital discharge.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Medical Center Groningen Coordinator of this site? Confirm its status | Groningen | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.