Efficacy Study II on Remote Ischemic Conditioning for the Prevention of Stroke-Associated Pneumonia

Prior treatment

• Anti-infective drug were used within 7 days prior to stroke;
• Use of immunosuppressive drug within the preceding 3 months;

Other illness

• Evidence of lung infection, urinary tract infection or other infectious diseases during the screening period
• Uncontrolled hypertension with medication (defined as systolic blood pressure ≥200 mmHg and/or diastolic blood pressure ≥110 mmHg);
• There are contraindications for remote ischemic conditioning (such as skin and soft tissue injury, fractures, peripheral arterial disease, etc. in the upper limbs);
• History of autoimmune disease or malignancies;
• Other conditions are not suitable for this trial as evaluated by researchers.

Other

• During the screening period, body temperature ≥ 38 ℃;
• Expected lifespan less than 7 days
• Mechanical ventilation is expected to be required within 7 days;
• Pregnant or lactating, or pregnancy test positive;
• Current participation in another investigational trial;

• Age≥18 years old;
• Diagnosis of acute ischemic stroke;
• Remote ischemic conditioning or sham-remote ischemic conditioning can be treated within 24 hours after stroke onset
• NIHSS score≥4;
• Subject or his or her legally authorized representative was able to provide informed consent.