NCT05983354Withdrawn
Oral Medications for the Management of Acute Migraine Headache in the Emergency Department
Oral v. Parenteral Medications for the Emergency Management of Acute Migraine: a Pilot Randomized Control Trial
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Reason given: The project proved not feasible to launch at Health Sciences North.
Brief summary (registry, in English)
The goal of this pilot randomized control trial is to assess the feasibility of our patient recruitment and data collection strategy ahead of a full scale RCT investigating the efficacy of oral v. parenteral medications in the management of acute migraine headaches in the emergency department. Patients will be randomly assigned to receive either (A) standard medical therapy for the treatment of acute migraine headache (metoclopramide and ketorolac IV) and oral placebo or (B) oral metoclopramide and ibuprofen with normal saline IV. Primary outcome measures are recruitment rate and improvement in pain score at 60 minutes from medication administration.
- Status (registry)
- Withdrawn
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 1 Aug 2023
- Start date
- 28 Jun 2023
- Primary completion date
- 7 Aug 2026
- Lead sponsor
- Health Sciences North Research Institute
- Diseases
- Migraine
- NCT number
- NCT05983354
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent use of blood thinners
Other illness
- Hypersensitivity reaction to any of the study medications
Other
- Vomiting or unable to tolerate PO at tie of med admin
- Focal neurologic symptoms
- Head trauma within 14d
- Pregnancy
- >14 HA days per month
Who the study is looking for
- Presentation to emergency department with headache
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.