NCT05990296Completed
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care (GREAT-HF Care)
Source: ClinicalTrials.gov · Last updated 19 Sept 2025
Brief summary (registry, in English)
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life. Despite convincing data that evidenced-based, guideline-directed medical therapies (GDMT) improve mortality and heart failure-related events, there remains insufficient utilization of these life-saving drugs (evidence-based beta-blockers (EBBB), angiotensin-neprilysin inhibitors (ARNI)/ angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARB), mineralocorticoid receptor antagonists (MRA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with HFrEF. The primary objective of this study is to implement and evaluate a multifaceted, interdisciplinary intervention to improve GDMT use, reduce mortality, and reduce future heart failure events in patients with HFrEF.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 4306 (actual)
- First submitted
- 31 Jul 2023
- Start date
- 1 Aug 2023
- Primary completion date
- 17 Feb 2025
- Lead sponsor
- Geisinger Clinic
- Diseases
- Heart failure
- NCT number
- NCT05990296
What you commit to
- Study type: Interventional
- Participants enrolled: 4306
- From 1 Aug 2023 to the primary completion date, 17 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient is prescribed medications from all four categories of GDMT, including ARNI specifically
Other illness
- Patient is allergic to each category of GDMT
Other
- Currently in hospice or palliative care (ICD 10 code: Z51.5)
Who the study is looking for
- Patients aged 18 years or older AND
- Completed visit at included Geisinger cardiology outpatient clinics (office visit or telemedicine) AND
- Clinicians are on a list of currently active Geisinger clinicians in outpatient cardiology clinics who can prescribe heart failure medications AND
- Active problem list diagnosis of HFrEF at time of Cardiology clinic encounter OR Left Ventricular Ejection Fraction (LVEF) \< 40: most recent to the cardiology clinic encounter within 2 years of the visit.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Geisinger Cardiology Clinics Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.