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NCT05993234Active, not recruiting

A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)

A Prospective Non-interventional Study (NIS) of Trastuzumab DeRuxtecan (T-DXd) for Adult Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction (GEJ) AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen, Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies in a Real-world Setting in Europe (PROSPERITY)

Source: ClinicalTrials.gov · Last updated 20 Aug 2026

Brief summary (registry, in English)

Trastuzumab deruxtecan (T-DXD) as monotherapy is indicated for the treatment of adult patients with advanced HER2-positive advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. This study will assess the effectiveness of T-DXd, patient demographic and clinical characteristics, and treatment patterns in patients with advanced HER2-positive advanced gastric or GEJ adenocarcinoma.

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
257 (estimated)
First submitted
2 Aug 2023
Start date
5 Dec 2023
Primary completion date
1 Dec 2026
Lead sponsor
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
NCT number
NCT05993234

What you commit to

  • Study type: Observational
  • Planned participants: 257
  • From 5 Dec 2023 to the primary completion date, 1 Dec 2026
  • 39 sites in 4 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Patients who at time of data collection for this study are participating in or have participated in an interventional study that remains blinded
  • Pregnancy or breastfeeding
    • No specific exclusion criteria are defined, as patients will be treated according to the proposed indication statements in the SmPC.

Who the study is looking for

  • Male or female adult patient (age ≥ 18 years) with HER2 + advanced gastric or GEJ adenocarcinoma who have received a prior trastuzumab based regimen
  • Histological or cytological confirmed diagnosis of advanced HER2 positive gastric cancer or GEJ
  • Documented HER2 + status (archival sample or recent sample prior 2L therapy)
  • Decision to newly initiate monotherapy T-DXd or conventional therapies per SMPC according to the physician's choice
  • Written dated and signed Informed Consent (ICF) to participate in the study

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (39)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Ordensklinikum Linz GmbH - Barmherzige Schwestern
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LinzAustriaUnknown status
Medizinische Universität Wien
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ViennaAustriaUnknown status
Kepler Universitätsklinikum
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WelsAustriaUnknown status
Landesklinikum Wiener Neustadt
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Wiener NeustadtAustriaUnknown status
Krankenhaus St. Vinzenz in Zams
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ZamsAustriaUnknown status
OLV Hospital Aalst
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AalstBelgiumUnknown status
Antwerp University Hospital
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EdegemBelgiumUnknown status
UZ Gent
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GhentBelgiumUnknown status
CHU Helora Hospital de La Louvière - Site Jolimont
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Haine-Saint-PaulBelgiumUnknown status
JESSA Hasselt
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HasseltBelgiumUnknown status
UZ Brussel
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JetteBelgiumUnknown status
MVZ am Klinikum Aschaffenburg
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AschaffenburgGermanyUnknown status
Vivantes Klinikum im Friedrichshain
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BerlinGermanyUnknown status
Charité Campus Benjamin Franklin
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BerlinGermanyUnknown status
MV-Zentrum für Hämatologie & Onkologie
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CologneGermanyUnknown status
University Hospital Essen
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EssenGermanyUnknown status
Alb Fils Kliniken GmbH
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GöppingenGermanyUnknown status
Hämatologisch Onkologische Praxis Eppendorf (HOPE)
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HamburgGermanyUnknown status
KRH, Klinikum Siloah
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HanoverGermanyUnknown status
Studienzentrum am Raschplatz GbR
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HanoverGermanyUnknown status
Gemeinschaftspraxis Dr. Haytham Kamal / Dr. David C. Dorn
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HanoverGermanyUnknown status
Klinikum rechts der Isar der Technischen Universität München
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MünchenGermanyUnknown status
Klinikum am Steinenberg Reutlingen
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ReutlingenGermanyUnknown status
CaritasKlinikum Saarbrücken
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SaarbrückenGermanyUnknown status
Praxis Onkologie Rheinsieg
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TroisdorfGermanyUnknown status
IRCCS "S. De Bellis"
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Castellana GrotteItalyUnknown status
ARNAS Garibaldi - PO Nesima
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CataniaItalyUnknown status
AOU Careggi
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FlorenceItalyUnknown status
IRCCS AOU San Martino
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GenovaItalyUnknown status
IRCCS Ospedale San Raffaele
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MilanItalyUnknown status
Fondazione IRCCS - Istituto Nazionale dei Tumori
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MilanItalyUnknown status
Azienda Ospedaliero - Universitaria di Modena
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ModenaItalyUnknown status
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
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NaplesItalyUnknown status
Università della Campania 'Luigi Vanvitelli'
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NaplesItalyUnknown status
Università degli studi di Napoli Federico II
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NaplesItalyUnknown status
AOU Pisana - Stabilimento Santa Chiara
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PisaItalyUnknown status
AUSL della Romagna - Ospedale "S. Maria delle Croci" di Ravenna
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RavennaItalyUnknown status
Policlinico Universitario Campus Bio-Medico
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RomaItalyUnknown status
AO "Cardinale Giovanni Panico"
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TricaseItalyUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.