NCT05993234Active, not recruiting
A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)
A Prospective Non-interventional Study (NIS) of Trastuzumab DeRuxtecan (T-DXd) for Adult Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction (GEJ) AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen, Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies in a Real-world Setting in Europe (PROSPERITY)
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
Trastuzumab deruxtecan (T-DXD) as monotherapy is indicated for the treatment of adult patients with advanced HER2-positive advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. This study will assess the effectiveness of T-DXd, patient demographic and clinical characteristics, and treatment patterns in patients with advanced HER2-positive advanced gastric or GEJ adenocarcinoma.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 257 (estimated)
- First submitted
- 2 Aug 2023
- Start date
- 5 Dec 2023
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT05993234
What you commit to
- Study type: Observational
- Planned participants: 257
- From 5 Dec 2023 to the primary completion date, 1 Dec 2026
- 39 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patients who at time of data collection for this study are participating in or have participated in an interventional study that remains blinded
- Pregnancy or breastfeeding
- No specific exclusion criteria are defined, as patients will be treated according to the proposed indication statements in the SmPC.
Who the study is looking for
- Male or female adult patient (age ≥ 18 years) with HER2 + advanced gastric or GEJ adenocarcinoma who have received a prior trastuzumab based regimen
- Histological or cytological confirmed diagnosis of advanced HER2 positive gastric cancer or GEJ
- Documented HER2 + status (archival sample or recent sample prior 2L therapy)
- Decision to newly initiate monotherapy T-DXd or conventional therapies per SMPC according to the physician's choice
- Written dated and signed Informed Consent (ICF) to participate in the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (39)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ordensklinikum Linz GmbH - Barmherzige Schwestern Coordinator of this site? Confirm its status | Linz | Austria | Unknown status |
| Medizinische Universität Wien Coordinator of this site? Confirm its status | Vienna | Austria | Unknown status |
| Kepler Universitätsklinikum Coordinator of this site? Confirm its status | Wels | Austria | Unknown status |
| Landesklinikum Wiener Neustadt Coordinator of this site? Confirm its status | Wiener Neustadt | Austria | Unknown status |
| Krankenhaus St. Vinzenz in Zams Coordinator of this site? Confirm its status | Zams | Austria | Unknown status |
| OLV Hospital Aalst Coordinator of this site? Confirm its status | Aalst | Belgium | Unknown status |
| Antwerp University Hospital Coordinator of this site? Confirm its status | Edegem | Belgium | Unknown status |
| UZ Gent Coordinator of this site? Confirm its status | Ghent | Belgium | Unknown status |
| CHU Helora Hospital de La Louvière - Site Jolimont Coordinator of this site? Confirm its status | Haine-Saint-Paul | Belgium | Unknown status |
| JESSA Hasselt Coordinator of this site? Confirm its status | Hasselt | Belgium | Unknown status |
| UZ Brussel Coordinator of this site? Confirm its status | Jette | Belgium | Unknown status |
| MVZ am Klinikum Aschaffenburg Coordinator of this site? Confirm its status | Aschaffenburg | Germany | Unknown status |
| Vivantes Klinikum im Friedrichshain Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Charité Campus Benjamin Franklin Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| MV-Zentrum für Hämatologie & Onkologie Coordinator of this site? Confirm its status | Cologne | Germany | Unknown status |
| University Hospital Essen Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| Alb Fils Kliniken GmbH Coordinator of this site? Confirm its status | Göppingen | Germany | Unknown status |
| Hämatologisch Onkologische Praxis Eppendorf (HOPE) Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| KRH, Klinikum Siloah Coordinator of this site? Confirm its status | Hanover | Germany | Unknown status |
| Studienzentrum am Raschplatz GbR Coordinator of this site? Confirm its status | Hanover | Germany | Unknown status |
| Gemeinschaftspraxis Dr. Haytham Kamal / Dr. David C. Dorn Coordinator of this site? Confirm its status | Hanover | Germany | Unknown status |
| Klinikum rechts der Isar der Technischen Universität München Coordinator of this site? Confirm its status | München | Germany | Unknown status |
| Klinikum am Steinenberg Reutlingen Coordinator of this site? Confirm its status | Reutlingen | Germany | Unknown status |
| CaritasKlinikum Saarbrücken Coordinator of this site? Confirm its status | Saarbrücken | Germany | Unknown status |
| Praxis Onkologie Rheinsieg Coordinator of this site? Confirm its status | Troisdorf | Germany | Unknown status |
| IRCCS "S. De Bellis" Coordinator of this site? Confirm its status | Castellana Grotte | Italy | Unknown status |
| ARNAS Garibaldi - PO Nesima Coordinator of this site? Confirm its status | Catania | Italy | Unknown status |
| AOU Careggi Coordinator of this site? Confirm its status | Florence | Italy | Unknown status |
| IRCCS AOU San Martino Coordinator of this site? Confirm its status | Genova | Italy | Unknown status |
| IRCCS Ospedale San Raffaele Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Azienda Ospedaliero - Universitaria di Modena Coordinator of this site? Confirm its status | Modena | Italy | Unknown status |
| Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| Università della Campania 'Luigi Vanvitelli' Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| Università degli studi di Napoli Federico II Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| AOU Pisana - Stabilimento Santa Chiara Coordinator of this site? Confirm its status | Pisa | Italy | Unknown status |
| AUSL della Romagna - Ospedale "S. Maria delle Croci" di Ravenna Coordinator of this site? Confirm its status | Ravenna | Italy | Unknown status |
| Policlinico Universitario Campus Bio-Medico Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| AO "Cardinale Giovanni Panico" Coordinator of this site? Confirm its status | Tricase | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.