NCT05996900Recruiting
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Source: ClinicalTrials.gov · Last updated 12 Mar 2026
Brief summary (registry, in English)
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 49 (estimated)
- First submitted
- 18 Jul 2023
- Start date
- 1 Sept 2023
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- Stanford University
- Diseases
- Epilepsy, Depression
- NCT number
- NCT05996900
What you commit to
- Study type: Interventional
- Planned participants: 49
- From 1 Sept 2023 to the primary completion date, 1 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any unstable medical condition
- Neurological or uncontrolled medical disease
Other
- Those with a contraindication for MRIs (e.g. implanted metal)
- Active substance abuse
- Currently pregnant or breastfeeding
Who the study is looking for
- Men and women, ages 18 to 65
- Medication-refractory epilepsy requiring phase II monitoring
- Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
- No current or history of major neurological disorders other than epilepsy
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.