NCT05997446Active, not recruiting
Amulet™ ADVANCE LAA
A Real-World Study to Observe Outcomes of Patients Undergoing Closure With the Amplatzer™ Amulet™ Left Atrial Appendage Occluder
Source: ClinicalTrials.gov · Last updated 1 Oct 2025
Brief summary (registry, in English)
This is a prospective, multicenter, observational study intended to characterize real-world outcomes on the commercially available Amulet device in the United States. Over 600 subjects have been enrolled at 16 US clinical sites. Subjects will be followed through 24 months in accordance with each site's standard care practices.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 610 (actual)
- First submitted
- 18 Jul 2023
- Start date
- Jul 2023
- Primary completion date
- Jun 2027
- Lead sponsor
- Abbott Medical Devices
- Diseases
- Stroke, Atrial fibrillation
- NCT number
- NCT05997446
What you commit to
- Study type: Observational
- Participants enrolled: 610
- From Jul 2023 to the primary completion date, Jun 2027
- 16 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of other conditions that, in the investigator's opinion, could limit the subject's ability to participate in follow-up
Who the study is looking for
- Intended for LAAO with the Amulet device
- At least 18 years of age
- Willing and capable of providing informed consent and participating in all testing associated with this clinical study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (16)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Trident Medical Center Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Baylor All Saints Medical Center at Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Baptist Medical Center Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Bryan Heart Coordinator of this site? Confirm its status | Lincoln | United States | Unknown status |
| Arkansas Heart Hospital Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| Pinnacle Health System Coordinator of this site? Confirm its status | Mechanicsburg | United States | Unknown status |
| Vanderbilt Heart & Vascular Institute Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| New York University Hospital Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| PERC - O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| CHI Health Creighton University Medical Center-Bergan Mercy Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Kansas City Cardiac Arrhythmia Research Foundation Coordinator of this site? Confirm its status | Overland Park | United States | Unknown status |
| Arizona Arrhythmia Research Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Heart Rhythm Associates Coordinator of this site? Confirm its status | Shenandoah | United States | Unknown status |
| Providence Hospital Coordinator of this site? Confirm its status | Southfield | United States | Unknown status |
| Cardiovascular Research Institute of Kansas Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Usman R. Siddiqui, MD Coordinator of this site? Confirm its status | Winter Park | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.