NCT05998772Recruiting
Influence of Glucose on Metabolism and Clinical Symptoms of Patients With Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 22 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Many patients with Parkinson's Disease (PD) report an increased consumption of fast-acting sugars. This tendency to consume sweet, high-sugar foods occurs in some patients even before the onset of cardinal motor symptoms. Some recent studies have demonstrated that PD patients have an increased consumption of fast-acting carbohydrates compared to healthy controls. However, the reason for this change in eating behavior has not yet been adequately explained. It is discussed that the increased sugar intake leads to an increased dopamine release in the brain via an increase in insulin and thus to an improvement in clinical symptoms. This study investigates the influence of fast-acting carbohydrates on insulin and glucose blood levels as well as motor and non-motor symptoms in patients with PD using an oral glucose tolerance test and a placebo oral glucose tolerance test in a crossover design.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 21 Jul 2023
- Start date
- 1 Sept 2023
- Primary completion date
- Dec 2025
- Lead sponsor
- University Hospital Schleswig-Holstein
- Diseases
- Parkinson disease
- NCT number
- NCT05998772
What you commit to
- Study type: Observational
- Planned participants: 50
- From 1 Sept 2023 to the primary completion date, Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other significant neurological diseases primarily affecting the central nervous system (e.g., multiple sclerosis)
- Diagnosis of diabetes mellitus or prediabetes
- cardiac or brain pacemakers
Lab values
- Use of medications that affect glucose metabolism, such as antidiabetics, glucocorticoids, ciclosporin, tacrolimus, sirolimus, beta-blockers, thiazide diuretics, beta-2 adrenoreceptor agonists, theophylline, Clozapine, olanzapine, paliperidone, quetiapine, risperidone, tricyclic antidepressants, mirtazapine, mianserin, carbamazepine, gabapentin, pregabalin, valproic acid, lithium, antiretroviral drugs, statins
Who the study is looking for
- Diagnosis of Parkinson's Disease, stage Hoehn \& Yahr 1.5-3
- Ability to pause antiparkinsonian medication in the morning without relevant impairment
- Capacity to give consent (determined in doubt by two independent neurologists, MOCA ≥18) and written informed consent.
- Patients are between 50 and 80 years of age, with exceptions for a maximum of 5 additional patients enrolled per group
- For stratification into patients with and without sweet craving, a 3-day dietary protocol should be completed once by the patients
- Group I: increased hunger for sweets.
- Group II: no increased hunger for sweets.
- For the stratification into patients with and without increased hunger for sweets, participants are asked to answer the following questions:
- Do you have sudden attacks of cravings for sweets?
- Would you say that your consumption of sweet food has increased in recent years?
- Would you describe your consumption of sugary food as increased or excessive?
- If one of the questions is answered with yes, participants will be assigned to group I, if all questions are answered with no, participants will be assigned to group II.
Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department for Neurology, University of Kiel Coordinator of this site? Confirm its status | Kiel | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.