NCT06001632Completed
Changes in Muscle Strength, Inflammatory Markers, and Body Composition in Response to Alternate Day Fasting Combined With Krill Oil Supplementation in Adults With Overweight and Obesity
Source: ClinicalTrials.gov · Last updated 17 Dec 2025
Brief summary (registry, in English)
The goal of this double-blind, randomised, controlled trial is to determine the effects of LC n-3 PUFAs supplementation on changes in body composition and muscle strength during body weight loss and body weight maintenance among healthy adults living with overweight and obesity. The main research questions: * Is supplementation with LC n-3 PUFAs during dietary weight loss intervention (alternative-day fasting) attenuate the reduction in fat-free mass and muscle strength? * Is supplementation with LC n-3 PUFAs during dietary weight loss intervention (alternative-day fasting) provide additional impact on appetite related hormones (Acylated ghrelin, GLP-1, and PYY) and cardiometabolic risk factors (Post prandial inflammatory markers and Triglycerides)? Participants will be randomly assigned to a PLACEBO (Mix-vegetables oil) or LC n-3 PUFAs group (krill oil) (1:1 basis). Both groups will follow a dietary weight loss intervention (Alternate-day fasting). The study will last for 20 weeks that divided into 3 phases: four weeks of the preparation phase, eight weeks of body weight loss phase (Alternate Day Fasting), followed by eight weeks of body weight maintenance phase (regular diet).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 50 (actual)
- First submitted
- 31 Jul 2023
- Start date
- 28 Mar 2022
- Primary completion date
- 1 Oct 2025
- Lead sponsor
- University of Glasgow
- Diseases
- Obesity
- NCT number
- NCT06001632
What you commit to
- Study type: Interventional
- Participants enrolled: 50
- From 28 Mar 2022 to the primary completion date, 1 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Food allergy
Other
- Smokers
- On any dietary supplements or dietary regimes at the time of the study
- Participants with systolic/diastolic \<90/60 mmHg and \>140/90 mmHg
Who the study is looking for
- Healthy (male/female)
- body mass index (BMI) of 25 - 39.9 kg/m2
- Aged between 25 and 65 years
- stable body weight for at least three months
Age in the registry: 25 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Glasgow, New Lister Building Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
Related publications
- Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial.Obesity (Silver Spring) · 2025 · PMID 40671417
This page is information, not medical advice. Discuss any trial with your doctor.