NCT06002204Active, not recruiting
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression (SHAKTI)
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
SHAKTI (from the Sanskrit word for "power") is a 5-year natural history, longitudinal, prospective study of a cohort of 6,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological, and neurobiological factors that contribute to antidepressant treatment response (remission, recurrence, relapse and individual outcomes in depressive disorders) and resilience. As this is an exploratory study, we will assess a comprehensive panel of carefully selected participant specific parameters - socio-demographic (age, sex, gender, race, ethnicity, economic); life habits (physical activity, substance use); clinical (medical history, anxious depression, early life trauma), biological (biomarkers in blood, saliva, urine, stool), behavioral (cognitive, emotional), neurophysiological (EEG), and neuroimaging (magnetic resonance imaging; MRI) with the goal of developing the most robust predictive models of depression treatment response and of outcomes.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 6000 (estimated)
- First submitted
- 15 Aug 2023
- Start date
- 1 Mar 2024
- Primary completion date
- Feb 2034
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- Depression, Bipolar disorder
- NCT number
- NCT06002204
What you commit to
- Study type: Observational
- Planned participants: 6000
- From 1 Mar 2024 to the primary completion date, Feb 2034
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of schizophrenia, schizoaffective disorders or chronic psychotic disorders based upon a semi-structured diagnostic interview.
- Has any condition for which, in the opinion of the investigator or designee, study participation would not be in their best interest (including but not limited to cognitive impairment, unstable general medical condition, intoxication, active psychosis) or that could prevent, limit, or confound the protocol-specified assessments.
- Requires immediate hospitalization for psychiatric disorder or suicidal risk as assessed by a licensed study clinician.
Other
- Unable to provide a stable home address and contact information.
Who the study is looking for
- Adult or youth aged 10 years or older
- Self-identify fully or partially as being of Asian or Pacific Islander descent such as: East Asian, South Asian, Southeast Asian, Southwest Asian, Central Asian, Oceanian, Pacific Islander, Polynesian, Micronesian, Melanesian
- Have the ability to speak, read, and understand English. The parent(s) or legal guardians of minors must also speak, read and understand English.
- Have the ability to complete clinical evaluations, neuropsychological testing, and self-report measures.
- Meet criteria for one of these three groups:
- Have a lifetime or a current diagnosis of a mood disorder (such as depression, bipolar disorder, anxiety) based upon a semi- structured diagnostic interview (must be a non-psychotic depressive disorder)
- Be at risk for developing mood disorders
- Healthy Control Group
Age in the registry: 10 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.