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NCT06005168CompletedPhase 4

Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis

Source: ClinicalTrials.gov · Last updated 30 Jan 2026

Brief summary (registry, in English)

The goal of this clinical study is to compare the dosing of an antibiotic in overweight patients having surgery. The main question\[s\] it aims to answer are: * Are the antibiotic concentrations in blood and fat tissue in patients that are overweight sufficient to prevent the chance of infection? * Can dosing using body composition rather than body weight improve the chance of achieving good antibiotic concentrations in overweight patients? Participants will allow us to collect small amounts of blood and fat tissue during their regularly scheduled surgery. Researchers will compare differences in antibiotic concentrations based on dosing by standard of care (body weight based) versus body composition.

Status (registry)
Completed
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
57 (actual)
First submitted
16 Aug 2023
Start date
8 Mar 2023
Primary completion date
1 Oct 2025
Lead sponsor
University of Michigan
Diseases
Obesity
NCT number
NCT06005168

What you commit to

  • Study type: Interventional · Phase 4
  • Participants enrolled: 57
  • From 8 Mar 2023 to the primary completion date, 1 Oct 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • History of a hypersensitivity reaction to penicillin or cephalosporin

Other

  • Pregnancy

Who the study is looking for

  • Accessible abdominal computed tomography scan prior to surgery
  • Adult patients \> 18 years of age
  • Body Mass Index ≥ 25 kg/m\^2
  • Expected to receive cefazolin prior to surgical incision
  • Estimated creatinine clearance ≥90 mL/min

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of Michigan Hospital
Coordinator of this site? Confirm its status
Ann ArborUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.