NCT06009276Recruiting
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
Source: ClinicalTrials.gov · Last updated 24 Dec 2025
Brief summary (registry, in English)
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a bike until you reach maximum effort. * Undergo blood draws * Wear a 24-hour non-invasive device that monitors blood pressure. * Drink 70mL (1/3 of a cup) of concentrated beetroot juice once
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 70 (estimated)
- First submitted
- 18 Aug 2023
- Start date
- 30 Aug 2023
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Virginia
- Diseases
- Heart failure, Obesity
- NCT number
- NCT06009276
What you commit to
- Study type: Observational
- Planned participants: 70
- From 30 Aug 2023 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Oral antibiotic use within previous four weeks
- Subjects taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (ex: Cialis, Viagra), and xanthine oxidase inhibitors (ex: Allopurinol).
Other illness
- Oral disease or poor oral health as determined by the Oral Health Questionnaire
- Hypersensitivity to any ultrasound contrast agent
Lab values
- Diagnosis of chronic renal failure (GFR \< 60 ml/min/1.73m)
Other
- Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
- Tobacco smokers
- Pregnant or lactating females
- Inability to perform exercise
- Unable to communicate effectively in English to the study team.
Who the study is looking for
- Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
- Subjects may be of either sex with age 18 years.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UVA Student Health and Wellness Building Coordinator of this site? Confirm its status | Charlottesville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.