NCT06013761Completed
IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant Epilepsy
Monocentric Randomized Experimental Pilot Trial Investigating the Influence of Intermittent Fasting According to the 16:8 Method With and Without Medium-chain Triglycerides (MCTs) on Seizure Frequency, Biomarkers and Neural Networks in Patients With Drug-resistant Epilepsy
Source: ClinicalTrials.gov · Last updated 4 Dec 2025
Brief summary (registry, in English)
The objective of the prospective monocentric pilot trial is to investigate the influence of intermittent fasting with or without a once-daily intake with medium chain triglycerides (MCTs) on the frequency of seizures in patients with therapy-refractory epilepsy. The effects of 12 weeks intermittent fasting according to the 16:8 method (IF 16:8) are compared to 12 weeks intermittent fasting with additional intake of exogenous MCTs (IF MCT 16:8) in a within-subject-crossover-design in 28 patients with drug-resistant epilepsy.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 22 (actual)
- First submitted
- 8 Aug 2023
- Start date
- 25 Jul 2023
- Primary completion date
- 31 May 2025
- Lead sponsor
- University Hospital Marburg
- Diseases
- Epilepsy
- NCT number
- NCT06013761
What you commit to
- Study type: Interventional
- Participants enrolled: 22
- From 25 Jul 2023 to the primary completion date, 31 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Metabolic disorder (e.g. diabetes, liver cirrhosis, kidney disease)
- Eating Disorder (e.g. anorexia, bulimia)
- Chronic inflammatory gut disease
- Active cancerous disease
Other
- Pregnancy
- Breast feeding period
- Antibiotics within the last 3 months
Who the study is looking for
- Subjects able to provide informed consent
- Drug-resistant epilepsy
- At least 3 seizures per month
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Philipps University Marburg, Faculty of Medicine, Department of Neurology, Epilepsy Center Coordinator of this site? Confirm its status | Marburg | Germany | Unknown status |
Related publications
- Intermittent fasting with medium-chain triglycerides in drug-resistant epilepsy: A pilot crossover trial.Epilepsia · 2026 · PMID 42360174
This page is information, not medical advice. Discuss any trial with your doctor.