NCT06013956RecruitingPhase 4
Personalized Real-Time DBS and PD Mechanisms
Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 25 (estimated)
- First submitted
- 22 Aug 2023
- Start date
- 29 Aug 2023
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- David Escobar
- Diseases
- Parkinson disease
- NCT number
- NCT06013956
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 25
- From 29 Aug 2023 to the primary completion date, 30 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's disease.
- Patient has a condition that, in the opinion of the investigators, would significantly increase the risk of interfering with study compliance, safety, or outcome.
Who the study is looking for
- Ability to provide informed consent.
- Clinical diagnosis of idiopathic Parkinson's disease.
- Determined, as per standard of care, to be a candidate for deep brain stimulation (DBS) surgery targeting the subthalamic nucleus.
- Ability to tolerate delays in taking daily standard Parkinson's disease medications.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.