NCT06014684Completed
Timing Exercise Training as Strategy to Improve Insulin Sensitivity and Substrate Metabolism in Men and Woman With Pre-diabetes
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
n a retrospective analysis of an exercise training program performed either in the morning or afternoon, we found that the afternoon training group improved their peripheral insulin sensitivity and fasting plasma glucose levels to a greater extent than the morning group. However, underlying mechanisms are unclear. The primary study endpoint is nocturnal glucose levels measured by a continuous glucose monitor (CGM).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 20 Jul 2023
- Start date
- 13 Jul 2023
- Primary completion date
- 31 Mar 2026
- Lead sponsor
- Maastricht University Medical Center
- Diseases
- Obesity
- NCT number
- NCT06014684
What you commit to
- Study type: Interventional
- Participants enrolled: 15
- From 13 Jul 2023 to the primary completion date, 31 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results.
- Medication use known to hamper subject's safety during the study procedures.
- Blood donation during or within 2 months prior to the study
Other illness
- Type 2 diabetes
- Patients with active congestive heart failure and and/or severe renal and or liver insufficiency
- Uncontrolled hypertension
- Significant food allergies/intolerance (seriously hampering study meals)
Lab values
- Men: Hb \<8.0 mmol/L, Women: Hb \<7.0 mmol/l
Other
- Any contra-indication for MRI scanning
- Alcohol consumption of \>3 servings per day for man and \>2 servings per day for woman
- Smoking
- Unstable body weight (weight gain or loss \> 5kg in the last 3 months)
- Subjects who do not want to be informed about unexpected medical findings.
- Heavily varying sleep-wake rhythm (i.e. night shift work and travels across time zones).
Who the study is looking for
- Aged 40-75 years.
- Body mass index (BMI) ≥25 kg/m2
- Male, or postmenopausal (at least 1 year post cessation of menses) female
- Pre-diabetes based on one or a combination of the following criteria:
- Impaired Glucose Tolerance (IGT): plasma glucose values ≥ 7.8 mmol/l and ≤ 11.1 mmol/l 120 minutes after glucose drink consumption during OGTT in screening
- ImpairedFastingGlucose(IFG):Fastingplasmaglucose≥6.1mmol/land≤6.9 mmol/l
- Insulin Resistance: glucose clearance rate ≤ 360 mL/kg/min, as determined during the OGTT using OGIS120.
- HbA1cof5.7-6.4%
Age in the registry: 40 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Maastricht University Coordinator of this site? Confirm its status | Maastricht | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.