NCT06015022RecruitingPhase 2
EGCG for Hepatocellular Carcinoma Chemoprevention
Phase II Randomized Controlled Trial of Epigallocatechin Gallate for Hepatocellular Carcinoma Chemoprevention
Source: ClinicalTrials.gov · Last updated 5 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This phase II trial tests epigallocatechin gallate (EGCG) for its efficacy and safety in preventing development of hepatocellular carcinoma (HCC) in patients with liver cirrhosis.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 9 Aug 2023
- Start date
- 1 Sept 2024
- Primary completion date
- 31 Aug 2028
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06015022
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 60
- From 1 Sept 2024 to the primary completion date, 31 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior or ongoing use of EGCG
Other illness
- History of adverse reaction to green tea products
Other
- Severe obesity (BMI \> 40 kg/m2)
- Active drinking
- EGCG treatment \<4 weeks or \<80% of planned regimen at the end of week 4
- HCC development during the study
Who the study is looking for
- Adults (≥ 18 years-old)
- Clinically and/or histologically diagnosed cirrhosis
- No active hepatic decompensation
- No prior history of HCC
- Adequate hematologic, hepatic, and renal function
- Karnofsky performance status score ≥70
- Both sexes and all racial/ethnic groups will be considered
- FIB-4 index \> 3.25
- High-risk PLSec at baseline
- Absence of HLA-B\*35:01
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Southwestern Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.