NCT06022848Completed
Quantitative Sensory Testing and Occipital Nerve Stimulator
Does Occipital Nerve Stimulation Alter Pain Response as Measured by Quantitative Sensory Testing in Patients With Chronic Migraine or Cluster Headache
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
The primary aim of this study is to assess the reversibility of a range of psychophysical markers of pain processing in patients with chronic migraine or cluster headache before and after ONS insertion and comparing to patients having a general anaesthetic (GA) for a non-painful aetiology at Barts Health NHS Trust. We will also compare with healthy volunteers not undergoing surgery. To establish whether pain perception alters in patients with chronic migraine/cluster headache having ONS using questionnaires and compare to patients having a general anaesthetic for a non- painful procedure D \& C at Barts Health NHS Trust. Are pain markers (Glutamate, TGF-B1) altered with ONS?
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 6 (actual)
- First submitted
- 28 Jun 2019
- Start date
- 1 Sept 2019
- Primary completion date
- 14 Jan 2026
- Lead sponsor
- Barts & The London NHS Trust
- Diseases
- Migraine
- NCT number
- NCT06022848
What you commit to
- Study type: Interventional
- Participants enrolled: 6
- From 1 Sept 2019 to the primary completion date, 14 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have received an investigational drug or have used an investigational device in the 30 days preceding to study entry
Other illness
- Patients with diabetes
- Patients known to have a condition that in the investigator's judgment precludes participation in the study.
Age
- Female patients of childbearing age who is or plans on becoming pregnant during the course of the study
Other
- Any inclusion criteria not met
Who the study is looking for
- Subject satisfies standard criteria in the study centre for ONS implantation and the NICE 452 criteria for intractable chronic migraine or cluster headache.
- Patients who have given their written informed consent.
- Patient is able and willing to comply with study procedures and follow up schedule.
- Participants will need a good understanding of the English Language and hence. This is a requirement not just for this research but also for the success of the interventions and the full understanding of QST.
- Patients undergoing surgery (non-painful complaint) 'dilatation and curettage' (D\&C).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Barts Health NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.