NCT06023407Enrolling by invitation
Feasibility of Improving Glycemia With Heat Therapy to Prevent AD
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
The investigators will determine if heat therapy can improve blood (Aim 1) and brain (Aim 2) glucose metabolism in cognitively healthy older adults (65+) who are at risk for AD. The investigators will also examine the degree to which changes in blood and brain glucose metabolism track together and explore several additional potential mechanisms that are critical to understanding the brain benefits of heat therapy (Aim 3). These aims will provide a comprehensive understanding of the impact of heat therapy on whole body metabolic function and brain health.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 Aug 2023
- Start date
- 27 Feb 2024
- Primary completion date
- 29 Oct 2027
- Lead sponsor
- University of Kansas Medical Center
- Diseases
- Alzheimer disease
- NCT number
- NCT06023407
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 27 Feb 2024 to the primary completion date, 29 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- ACSM Risk score stratification of "High" unless cleared by a physician prior to participation.
Other illness
- Myocardial infarction or symptoms of coronary artery disease in the last 2 years.
- History of or current diagnosis of disorders with the potential to impair cognition (i.e. AD, Parkinson's disease, stroke (defined as clinical episode w/ neuroimaging evidence in appropriate area to explain symptoms)).
- Insulin-dependent (Type 1) Diabetes Mellitus.
- Clinically significant chronic disease such as cancer, HIV, or acquired immunodeficiency syndrome.
- Clinically significant depressive symptoms that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment.
- Untreated hypothyroidism or diseases associated with heat intolerance (i.e. Graves disease, etc).
- Contraindication for temperature pill ingestion (i.e. inflammatory bowel disease, diverticulitis or related).
Lab values
- Excluded from or unable to complete an MRI scan. MRI compatible pacemakers will require cardiologist clearance prior to enrolling.
Other
- Orthopedic complications that would preclude individuals from safely entering a hot tub.
Who the study is looking for
- Age 65 and older
- Stable medication doses (\>1 month)
- Post-menopausal
- Clinical Dementia Rating (CDR) of 0
- History of or current metabolic impairment (i.e. metabolic syndrome, pre-diabetes, Type 2 Diabetes, etc)
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Univeristy of Kansas Medical Center Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
Related publications
- Heat therapy in individuals at risk for Alzheimer's disease-methods for a randomized controlled trial.Front Neurol · 2026 · PMID 41657418
This page is information, not medical advice. Discuss any trial with your doctor.