NCT06024291Completed
Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Trial
Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Randomised Controlled Exercise Trial
Source: ClinicalTrials.gov · Last updated 15 May 2025
Brief summary (registry, in English)
The purpose of this study is to assess the effects of an 8-week supervised high-intensity interval training (HIIT) program (vs. physical activity recommendations according to current guidelines) on a comprehensive panel of circulating sphingolipids in middle-aged females and males at elevated cardiometabolic risk.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 88 (actual)
- First submitted
- 28 Aug 2023
- Start date
- 15 Sept 2023
- Primary completion date
- 15 Jan 2025
- Lead sponsor
- University of Basel
- Diseases
- Obesity
- NCT number
- NCT06024291
What you commit to
- Study type: Interventional
- Participants enrolled: 88
- From 15 Sept 2023 to the primary completion date, 15 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- intake of glucagon-like peptide-1 analogues, orlistat or any weight-loss drug,
- concomitant involvement in another interventional trial or participation in another interventional trial in the last four weeks.
Other illness
- any current exercise-limiting musculoskeletal conditions of the lower limbs,
- any known current or chronic conditions limiting exhaustive exercise,
- known diabetes mellitus of any type,
- arterial hypertension ≥160/100 mmHg, pharmaceutically treated or not,
- any other known cardiovascular disease,
Other
- known pregnancy or breastfeeding,
- dyslipidaemia, if pharmaceutically treated,
- known NASH,
- known macular degeneration, glaucoma, or high intraocular pressure (≥20 mm Hg),
- particular diet (vegetarian, vegan, lactose-free, gluten-free, or FODMAP-low diet (ferment-able oligosaccharides, disaccharides, monosaccharides, and polyols),
- inability to follow the procedures of the study, e.g., due to linguistic or cognitive problems,
Who the study is looking for
- female or male sex,
- aged between 40 and 60 years,
- body mass index between 25.0 and 34.9 kg/m2,
- sedentary lifestyle, defined as not meeting the WHO guidelines on PA, i.e., at least 150 minutes of moderate-intensity aerobic PA per week as well as muscle-strengthening activities on two or more days per week,
- medical clearance for HIIT by a study physician (including vital sign evaluation, clinical examination, resting and exercise ECG),
- informed consent as documented by signature.
Age in the registry: 40 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Sport, Exercise and Health, University of Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.