NCT06025383Completed
2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension
2 Weeks of L-Citrulline Supplementation Improves Arterial Function and Systolic Blood Pressure at Rest and During Exercise in Postmenopausal Women With Elevated Blood Pressure and Hypertension
Source: ClinicalTrials.gov · Last updated 15 May 2025
Brief summary (registry, in English)
The objective of this project is to elucidate the effect of L-Citrulline (L-CIT) supplementation on vascular function at rest and during rhythmic handgrip exercise and functional sympatholysis via lower-body negative pressure in postmenopausal women with elevated blood pressure and hypertension.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 19 (actual)
- First submitted
- 19 Aug 2023
- Start date
- 20 Jul 2023
- Primary completion date
- 1 Jul 2024
- Lead sponsor
- Texas Tech University
- Diseases
- High blood pressure
- NCT number
- NCT06025383
What you commit to
- Study type: Interventional
- Participants enrolled: 19
- From 20 Jul 2023 to the primary completion date, 1 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking more than two antihypertensive medications.
- Changes in hypertensive medication in the past three months.
- Began or changed hormone replacement therapy in the past 6 months.
Other illness
- Cardiovascular diseases, type I/II diabetes, musculoskeletal disorders, or cancer.
Other
- Body mass index ≥ 40 or \< 25 kg/m2.
- Systolic blood pressure \> 150 mmHg.
- Current smoker.
- Heavy drinking (\> 7 alcoholic drinks/week).
- Participants on beta-blockers or other vasodilatory supplements (nitrates).
- Incorporated in a weight loss program and/or aerobic or resistance training program.
Who the study is looking for
- Postmenopausal women (defined as the absence of menstruation for at least 1 year).
- Resting systolic blood pressure 120-150 mmHg.
- Between the ages of 50 - 70 years.
- Sedentary (\< 120 minutes of exercise/week).
- Body mass index of 25 - 39.9 kg/m2.
- Fasting glucose \< 126 mg/dL and HbA1c \< 6.5%.
Age in the registry: 50 years to 70 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Texas Tech University Coordinator of this site? Confirm its status | Lubbock | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.