NCT06027294Recruiting
Blood Flow Regulation and Neuromuscular Function Post-Stroke
Source: ClinicalTrials.gov · Last updated 25 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 30 Aug 2023
- Start date
- 11 Jan 2024
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Stroke
- NCT number
- NCT06027294
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 11 Jan 2024 to the primary completion date, 30 Jun 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Myocardial infarction in the previous year
Other illness
- History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
- Chronic pain syndrome
- History of head trauma
- Comorbid neurological disorder
- Peripheral vascular disease
- Condition where fatiguing contractions or resisted leg contractions are contraindicated
Other
- Low back or hip pain that interferes with lower extremity motor testing
- Inability to follow 2 step commands
- Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
- Pregnancy or breastfeeding.
Who the study is looking for
- Be between 18-85 years of age
- Able to give informed consent
- ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
- English speaking
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Marquette University Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.