NCT06030193CompletedPhase 2
Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG)
A Randomized, Active-controlled, Multi-site, Double-masked, Pilot Study to Evaluate the Safety and Tolerability of QLS-111 Versus Timolol Maleate Preservative Free 0.5% Ophthalmic Solution in Subjects With Normal Tension Glaucoma (NTG)
Source: ClinicalTrials.gov · Last updated 3 Apr 2026
Brief summary (registry, in English)
Qlaris' Phase 2 clinical trial investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in normal tension glaucoma patients.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 37 (actual)
- First submitted
- 18 Aug 2023
- Start date
- 13 Aug 2025
- Primary completion date
- 23 Feb 2026
- Lead sponsor
- Qlaris Bio, Inc.
- Diseases
- Glaucoma
- NCT number
- NCT06030193
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 37
- From 13 Aug 2025 to the primary completion date, 23 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe glaucomatous damage that would preclude safe washout of prescribed ocular hypotensive medications
- Previous glaucoma surgery, certain procedures (trabeculotomy, shunt/tubes, cyclodestructive procedure) (selective laser trabeculoplasty (SLT) allowed if done no earlier than 1 year from study, some minimally invasive glaucoma surgeries are allowed if done no earlier than 1.5 years from study)
- Use of other ophthalmic concomitant medications during the study
- Refractive surgery
- Participation in other investigational trial 30 days prior to screening or previous enrollment and treatment with Qlaris investigational product
Other illness
- History of angle closure glaucoma, narrow or occludable angle on gonioscope
- Ocular trauma, ocular infections, ocular inflammation, herpes simplex keratitis of eye
- Uncontrolled hypertension or hypotension
- Significant systemic or psychiatric disease
Other
- All secondary glaucomas
- Pregnant or lactating
Who the study is looking for
- 30 years or older
- Able to provide written acknowledgement of giving informed consent
- Best corrected visual acuity (BCVA) 20/200 or better
- NTG in both eyes with untreated IOP \<21 mmHg at Visit 2 and morning assessment of Visit 3; IOP at morning assessment on Visits 2 and 3 doesn't differ more than 2 mmHg; has open iridocorneal angles, historic IOP \<22 mmHg in either eye
Age in the registry: 30 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.