NCT06030895Completed
Sorafenib In Egyptian Patients With Hepatocellular Carcinoma.
Pharmacogenetic Study of Sorafenib In Egyptian Patients With Hepatocellular Carcinoma.
Source: ClinicalTrials.gov · Last updated 12 Mar 2024
Brief summary (registry, in English)
This study aims to determine the predictive effect of ATG10 and IL6 genetic polymorphisms in safety and efficacy of sorafenib used for the treatment of Egyptian HCC patients. Moreover, this study will determine the association between genetic polymorphisms of ATG10 and IL6 with HCC severity.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 100 (actual)
- First submitted
- 3 Sept 2023
- Start date
- 12 Dec 2022
- Primary completion date
- 21 Feb 2024
- Lead sponsor
- Damanhour University
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06030895
What you commit to
- Study type: Interventional
- Participants enrolled: 100
- From 12 Dec 2022 to the primary completion date, 21 Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient who are indicated for surgical resection or liver transplant (MDT).
Other illness
- Renal failure requiring hemo- or peritoneal dialysis
- History of cardiac disease
- Active clinically serious infections
- Known history of human immunodeficiency virus (HIV) infection
Age
- Age \> 75 years.
Other
- Patients refused to sign the written consent.
- Pregnant female
- Child-pugh class B and C.
- Performance status 3 or 4.
Who the study is looking for
- A diagnosed HCC patient.
- Child-pugh class A.
- Performance status 1-2 (ECOG scale)
- Laboratory investigation : Hemoglobin ≥8.5 mg\\dl, INR ≤2.3 ,Albumin≥2.8g\\dl, ALT and AST ≤ 3 times the ULN
- Age ≥20 years.
Age in the registry: 20 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mansoura university Hospital Coordinator of this site? Confirm its status | Al Mansurah | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.