NCT06036914CompletedPhase 2
A Study of Ultra High Dose Diuretics to Treat Heart Failure
Ultra High Dose Diuretic Strategy for Management of Acute Decompensated Heart Failure - A Randomized, Double-Blind Pilot Trial
Source: ClinicalTrials.gov · Last updated 14 Jan 2026
Brief summary (registry, in English)
The purpose of this study is to determine the safety and effectiveness of ultrahigh dose diuretics compared to standard dose diuretics over 24 hours in patients with decompensated heart failure.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 7 Sept 2023
- Start date
- 27 Nov 2023
- Primary completion date
- 8 Oct 2024
- Lead sponsor
- Mayo Clinic
- Diseases
- Heart failure
- NCT number
- NCT06036914
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 20
- From 27 Nov 2023 to the primary completion date, 8 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients on home inotrope medications
Other illness
- Patients with Chronic Kidney disease stage V and end stage renal failure on dialysis
- Complex congenital heart disease
- Allergy to furosemide or bumetanide
- Respiratory failure requiring non-invasive ventilation (CPAP/BiPAP) or invasive mechanical ventilatory support at the time of randomization
- Acute coronary syndrome
Other
- Patients lacking the capacity to consent for themselves
- Known pregnancy or breastfeeding mothers
- Hypotension with systolic blood pressure \<80 mm Hg at the time of randomization
- Sustained Ventricular tachycardia requiring treatment in the last 48 hours
- Patients weighing ≤ 40 kg
Who the study is looking for
- Diagnosis of decompensated heart failure receiving intravenous diuretics
- Ability to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.