NCT06040073Recruiting
Natural History of Coronary Atherosclerosis
Natural History of Coronary Atherosclerosis Based on Multimodal Imaging and Physiological Fusion Techniques (NASCENT)
Source: ClinicalTrials.gov · Last updated 6 Nov 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed by optical coherence tomography (OCT). The lesion progression at 1 year was defined as an increase of ≥20% in diameter stenosis based on quantitative coronary angiography (QCA) evaluation.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 125 (estimated)
- First submitted
- 3 Sept 2023
- Start date
- 7 Jul 2024
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- China National Center for Cardiovascular Diseases
- Diseases
- Coronary artery disease
- NCT number
- NCT06040073
What you commit to
- Study type: Observational
- Planned participants: 125
- From 7 Jul 2024 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- General exclusion Criteria:
- Cardiogenic shock
- Pregnant or woman of child-bearing potential
- Life expectancy less than 1 year for non-cardiac causes
- Unable to tolerate contrast agents or anticoagulant/antiplatelet therapy
- Prior CABG or planned CABG
- Angiographic exclusion Criteria:
- Poor angiographic image quality precluding vessel contour detection or with suboptimal contrast opacification, branch ostium cannot be shown clearly, severe overlap in the stenosed segment or severe tortuosity of any interrogated vessel deemed not amenable to QFR or RWS measurement
- An interrogated lesion require surgical bypass grafting
- Unable to judge culprit lesion or infarct-related artery according to current evidence
Who the study is looking for
- General Inclusion Criteria:
- Age ≥18 years
- Acute myocardial infarction ≤ 45 days
- Planned coronary angiography examination or potential interventional treatment
- Angiographic Inclusion Criteria:
- The presence of at least 1 non-flow-restricting lesion (visually estimated diameter stenosis: 30%-80%; QFR \> 0.80) in any non-infarct related artery with RVD ≥2.5 mm by visual assessment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lei Song Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.